IBS School
박주민 교수
연구위원, 인지 및 사회성 연구단, 기초과학연구원
E-mail: joominp@ibs.re.kr
Research Topic
Neuromodulation of Behavior, Genes to Brain
Our laboratory's primary goal is to develop non-invasive neural modulation algorithms that reliably enhance brain function over the long term. To achieve this, we utilize electrophysiology and in vivo imaging to understand brain signal transmission and network interactions, aiming to modulate neuroplasticity non-invasively in both normal brain function and models of brain disorders and neurological conditions.
The core of our research focuses on non-invasive ultrasonic neuromodulation. Our objective is to develop innovative ultrasonic neuromodulation techniques that modulate brain activity without surgical intervention, thereby enhancing brain function safely and effectively.
We are developing new non-invasive ultrasonic neuromodulation technologies for clinical applications while also exploring alternative treatments for neurological and psychiatric disorders. To this end, we employ various electrophysiological and behavioral analysis techniques, including Whole-Cell Patch Configuration, Brainwave (EEG) Recording, High-Resolution Fluorescence Microscopy, Optogenetics, and Behavioral Modeling of Impaired Sensorimotor Gating.
Our research aims to thoroughly understand the neural circuits and synaptic plasticity involved in learning and memory. These creative and challenging projects are expected to significantly contribute to the growth of young researchers and expand our academic influence both domestically and internationally.
Research Interests
Neural plasticity, Learning & memory, Non-invasive neuromodulation technique development, Synaptic plasticity, Acoustic neuromodulation
학력
- 학사, 서강대학교 (1997) – Biology
- 석사, 서울대학교 의과대학 (2000) – Physiology
- 박사, 서울대학교 의과대학 (2004) – Physiology
주요 경력
- 2004 - 2010 박사후 연수과정, 존스홉킨스 의과대학 신경과학부
- 2010 - 2012 Research Associate, 존스홉킨스 의과대학 신경과학부
- 2012 - 2015 조교수, 제주대학교 의과대학 생리학교실
- 2015 - 2020 연구위원 (영년직 트랙), 인지 및 사회성 연구단, 기초과학연구원
- 2017 - 교수, IBS-UST
- 2020 - 연구위원, 인지 및 사회성 연구단, 기초과학연구원
수상 실적
- 2014 제주대 우수과학자상
PUBLICATIONS (in the past 5 years)
- Kim et al., Long-lasting Forms of Plasticity through Patterned Ultrasound-induced Brainwave Entrainment, Science Advances, 2024
- Phan et al., BDNF/TrkB Signaling Inhibition Suppresses Astrogliosis and Alleviates Mechanical Allodynia in a Partial Crush Injury Model, Experimental Neurobiology, 2023
- Lee et al., Ultrasonocoverslip: In-Vitro Platform for High-Throughput Assay of Cell Type-Specific Neuromodulation with Ultra-low-intensity Ultrasound Stimulation, Brain Stimulation, 2023
- Lee et al., Enhanced mitochondrial DNA editing in mice using nuclear-exported TALE-linked deaminases and nucleases, Genome Biology, 2022
- Lin et al., Homer1a Regulates Shank3 Expression and Underlies Behavioral Vulnerability to Stress in a Model of PhelanMcDermid Syndrome, Cell Reports, 2021
- Lee et al., Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice, Nature Communications, 2021
- Kim et al., Histone demethylase PHF2 activates CREB and promotes memory consolidation, EMBO Reports, 2019
- Kim et al., Association of mGluR-Dependent LTD of Excitatory Synapses with Endocannabinoid-Dependent LTD of Inhibitory Synapses Leads to EPSP to Spike Potentiation in CA1 Pyramidal Neurons. Journal of Neuroscience, 2019
