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Research Topic

Neuromodulation of Behavior, Genes to Brain

Our laboratory's primary goal is to develop non-invasive neural modulation algorithms that reliably enhance brain function over the long term. To achieve this, we utilize electrophysiology and in vivo imaging to understand brain signal transmission and network interactions, aiming to modulate neuroplasticity non-invasively in both normal brain function and models of brain disorders and neurological conditions.

The core of our research focuses on non-invasive ultrasonic neuromodulation. Our objective is to develop innovative ultrasonic neuromodulation techniques that modulate brain activity without surgical intervention, thereby enhancing brain function safely and effectively.

We are developing new non-invasive ultrasonic neuromodulation technologies for clinical applications while also exploring alternative treatments for neurological and psychiatric disorders. To this end, we employ various electrophysiological and behavioral analysis techniques, including Whole-Cell Patch Configuration, Brainwave (EEG) Recording, High-Resolution Fluorescence Microscopy, Optogenetics, and Behavioral Modeling of Impaired Sensorimotor Gating.

Our research aims to thoroughly understand the neural circuits and synaptic plasticity involved in learning and memory. These creative and challenging projects are expected to significantly contribute to the growth of young researchers and expand our academic influence both domestically and internationally.

Research Interests

Neural plasticity, Learning & memory, Non-invasive neuromodulation technique development, Synaptic plasticity, Acoustic neuromodulation

Education

• BS, Sogang University (1997) – Biology
• MS, Seoul National University College of Medicine (2000) - Physiology
• PhD, Seoul National University College of Medicine (2008) - Physiology

Major Experience

• 1997 Sogang University
• 2004 PhD. Department of Physiology, Seoul National University College of Medicine
• 2004 - 2010 Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University School of Medicine
• 2010 - 2012 Research Associate, Department of Neuroscience, Johns Hopkins University School of Medicine
• 2012 - 2015 Assistant Professor, Department of Physiology, Jeju National University School of Medicine
• 2015 - 2020 Research Fellow (Tenure-track), Center for Cognition and Sociality, IBS
• 2017 - Professor, IBS-UST
• 2020 - Senior Research Fellow, Center for Cognition and Sociality, IBS

Honors

• 2014 The distinguished Scientist Support program funded by Jeju National University

Major Publication

• Homer1a Regulates Shank3 Expression and Underlies Behavioral Vulnerability to Stress in a Model of PhelanMcDermid Syndrome, Cell Reports, 2021
• Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice, Nature Communications, 2021
• Histone demethylase PHF2 activates CREB and promotes memory consolidation, EMBO Reports, 2019
• A Prolyl-isomerase Mediates Dopamine-dependent Plasticity and Cocaine Motor Sensitization, Cell, 2013
• Homeostatic scaling requires group I mGluR activation mediated by Homer1a, Neuron, 2010

Research

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