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Research Centers

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DirectorJae-Sung Woo

  • Jae-Sung Woo DirectorJae-Sung Woo

Biomolecular Sociology Group

Address

Biomolecular Sociology Group, Institute for Basic Science
55, Expo-ro, Yuseong-gu, Daejeon, Republic of Korea Zip: 34126
Room C233, Experiment Building (C-Wing), Institute for Basic Science HQs

Major Publications

more paper
  • - Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM (Nature Communications, 2023)
  • - Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel (Nature Communications, 2023)
  • - Adenine base editor engineering reduces editing of bystander cytosines (Nature biotechnology, 2021)
About CI
Director Jae-Sung Woo

Director Jae-Sung Woo

Director Jae-Sung Woo is a world-renowned researcher in the field of structural biology. He has pioneered research on the structure and function of membrane proteins to understand the principles and regulatory mechanisms of direct intercellular communication.

Introduction
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The Center for Biomolecular and Cellular Structure was founded in 2018 to explore the structure and function of biological macromolecules and organelles. The Biomolecular Sociology Group joined the Center in 2024. Using cryogenic electron microscopy and tomography techniques, the group aims to elucidate the structures and interactions of molecules within cells and understand biological processes at the atomic level. The primary research goal of the group is to understand the principles of direct intercellular communication through gap junctions. This research will greatly advance our understanding of biological processes in which gap junctions play a critical role, such as normal brain function, synchronized contraction of cardiomyocytes, and insulin secretion dynamics.

Main research activities
  • - The Biomolecular Sociology Group studies the structures and action mechanisms of membrane proteins and protein-RNA complexes using cryogenic electron microscopy (cryo-EM).
  • - The group studies the in situ structure of gap junction plaques, membrane microdomains, and membraneless organelles using cryogenic electron tomography (cryo-ET).
  • - The group develops sample preparation technology to increase the resolution of tomograms.
  • - By training cryo-ET experts, the group encourages the expansion of in situ structural biology in Korea and prepare for a surge in demand in the near future.
Research

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Last Update 2025-02-03 14:52