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Major Experience

• 1997 Sogang University
• 2004 PhD. Department of Physiology, Seoul National University College of Medicine
• 2004-2010 Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University School of Medicine
• 2010-2012 Research Associate, Department of Neuroscience, Johns Hopkins University School of Medicine
• 2012-2015 Assistant Professor, Department of Physiology, Jeju National University School of Medicine
• 2015- Research Fellow (Tenure-track), Center for Cognition and Sociality, IBS

Honors

• The distinguished Scientist Support program funded by Jeju National University (2014)

Major Publication

• mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Neuron 57(6): 858-871, 2008
• Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59(1): 70-83 (*equal contribution), 2008
• Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nature Neuroscience 13(9): 1090-1097,2010
• Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 68:1128-1142 (*equal contribution), 2010
• Preso1 dynamically regulates group I metabotropic glutamate receptors. Nature Neuroscience 15(6):836-844, 2012
• Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Science Translational medicine 5(201):201ra120, 2013
• A Prolyl-isomerase Mediates Dopamine-dependent Plasticity and Cocaine Motor Sensitization. Cell 154(3):637-650 (*equal contribution), 2013
• Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization. Korean Journal of Physiology and Pharmacology 18(6):457-460
• mGluR1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol 115: 2446-2455, 201
• Protein Arginine Methylation Facilitates KCNQ Channel-PIP2 Interaction Leading to Seizure Suppression. eLife 2016;5:e17159, 2016
• Real-Time Imaging Reveals Properties of Glutamate-Induced Arc.Arg3.1 Translation in Neuronal Dendrites. Neuron 91: 561-573, 2016

Research

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