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남홍길

DirectorNAM Hong Gil

  • NAM Hong Gil DirectorNAM Hong Gil
  • HWANG Daehee Associate DirectorHWANG Daehee
  • KWAK June M. Group LeaderKWAK June M.

Presenting a new paradigm in the studies of senescence and life-history strategies

Contact Info

Tel. +82-53-785-1804

Address

IBS Center for Plant Aging Research
DGIST R5, Techno jungang-daero 333, Hyeonpung-myeon, Dalseong-gun, Daegu

Director
Director NAM Hong Gil

Director NAM Hong Gil

Professor Nam is the director of the Center for Plant Aging Research, established in December 2012. In 1985 he received his Ph.D. in Chemistry from the University of North Carolina, Later, in 1986 he became a research fellow at the Department of Genetics at Harvard University. In 2012 he was awarded the position of Fellow at Daegu Gyeongbuk Institute of Science and Technology (DGIST) before taking up his position in IBS.

Introduction
graphic image for Research Center

Understanding life history strategies and senescence at the system-level

  • - Defining spatio-temporal network dynamics of key regulatory modules by adopting the methodology of molecular genetics and seeking a system-level understanding
  • - Identifying key molecular and cellular mechanisms regulating the life cycle of plants
  • - Elucidating influences of endogeneous and exogeneous signals on the life cycle of plants
  • - Identifying the meaning of the life history strategy and senescence in terms of evolution
  • - Developing methods to improve the productivity of crop plants by controlling their life history strategies and senescence
Main research activities

Plant senescence and death represent a very important and unique aspect of life: While most biological studies are concerned with how biogenesis is achieved, plant senescence provides a novel window to the ways in which the orderly, regulated disassembly of cells, organs, and organisms occurs. Plant senescence and death have a biological purpose in the sense that the nutrients derived from the disassembly process are passed on to progeny as a parental investment. In fact, many of the grains we eat are "nutrients" derived from the senescing leaves of crops. The modulation of senescence therefore has huge potential to improve plant productivity. One of biology's unresolved fundamental questions is this: How is time and the aging process incorporated in the developmental cycle of plant senescence?

The overall goal of this project is to gain insight into the system-level senescence and cell-death processes of plants, from the perspective of a life-history strategy. Acquiring such knowledge at molecular, cellular, intercellular, organ, and organismal levels will lead to breakthroughs that significantly improve plant productivity.

We intend to build core technology units in cooperation with group leaders and Daegu Gyeongbuk Institute of Science and Technology (DGIST), focusing our efforts on the computational unit, super-resolution and sensitivity-imaging unit, chemical genetics unit, systems genetics unit, and phenome unit. All the core technology units will be world-class, world-leading operations.
This study will provide an unprecedentedly detailed understanding of molecular events that clearly illustrates spatio-temporal multilayered networks and modules on this scientifically interesting and important subject. Furthermore, because plant productivity is highly influenced by senescence, our study can significantly contribute to resolving global problems (e.g., food and energy shortages; excessive carbon dioxide emissions). All organisms undergo aging and eventually die. Life history, senescence, and death are fundamental and philosophical matters for human beings. This study, which creates new paradigms for understanding life history and senescence, may also provide a crucial breakthrough in our understanding of age-dependent senescence and death.

Organization

Organization

Main research results
  • RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
    (Nature Communications, 2017)
  • L-Met Activates Arabidopsis GLR Ca2+ Channels Upstream of ROS Production and Regulates Stomatal Movement
    (Cell Reports, 2016)
  • Functional characterization of EI24-induced autophagy in the degradation of RING domain E3 ligases
    (Autophagy, 2016)
  • Age-associated circadian period changes in Arabidopsis leaves
    (Journal of Experimental Botany, 2016)
  • miR-204 downregulates EphB2 in Aging Mouse Hippocampal Neurons
    (Aging Cell, 2016)
  • C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
    (Nature communications, 2015)
  • RNA helicase HEL-1 promotes longevity by specifically activating the DAF-16/FOXO signaling in Caenorhabditis elegans
    (PNAS, 2015)
  • Microdroplet Fusion Mass Spectrometry for Fast Reaction Kinetics
    (PNAS, 2015)
  • Young Capillary Vessels Rejuvenate Aged Pancratic Islets
    (PNAS, 2014)
  • Balanced Nucleocytosolic Partitioning Defines a Spatial Network to Coordinate Circadian Physiology in Plants
    (Development Cell, 2013)
Personnel
Personnel status
Total96
Gender49(Male), 47(Female)
Korean/ International86(Korean), 10(International)
Degree
Position

As of March. 2017

Research

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Content Manager
Center for Plant Aging Research : Lim Su Bin   053-785-1844
Last Update 2017-07-05 15:08