IBS School
박주민 교수
연구위원, 인지 및 사회성 연구단, 기초과학연구원
E-mail: joominp@ibs.re.kr
Research Topic
Neuromodulation of Behavior, Genes to Brain
Our interest centers upon the development of new non-invasive neuromodulation techniques and the mechanisms of synaptic dysfunction in neuropsychiatric disorders. Despite the development and use of various neuromodulation techniques, the invention of non-invasive neuromodulation techniques that can selectively stimulate only certain circuits or cells in the brain has yet to be established. Compared to optogenetics, TMS and tDCS, cellular and molecular mechanisms of the ultrasound neuromodulation are poorly understood, but its importance is now emerging. Our new strategy using ultrasonic frequency modulation and sonogenetics can readily be applied to treatment and modulation for brain dysfunction associated with too much or too little neural plasticity. Another research topic is the physiological and molecular mechanisms underlying dysfunctional sensorimotor gating, which focuses on the role of GABAergic interneuron (IN) in E/I balance.
Indeed, GABAergic-IN dysfunction has been implicated in the etiology of various psychiatric disorders such as depression, autism, and schizophrenia. This suggests that modulation of inhibitory GABAergic circuits can have a reflective effect on the synaptic connection of neural network. This research will provide benefits, especially considering further translation into therapeutic drug discovery to treat impaired sensorimotor gating and cognition.
Research Interests
Neural plasticity, Learning & memory, Non-invasive neuromodulation technique development, Synaptic plasticity, Acoustic neuromodulation
학력
- 학사, 서강대학교 (1997) – Biology
- 석사, 서울대학교 의과대학 (2000) – Physiology
- 박사, 서울대학교 의과대학 (2004) – Physiology
주요 경력
- 2004 - 2010 박사후 연수과정, 존스홉킨스 의과대학 신경과학부
- 2010 - 2012 Research Associate, 존스홉킨스 의과대학 신경과학부
- 2012 - 2015 조교수, 제주대학교 의과대학 생리학교실
- 2015 - 2020 연구위원 (영년직 트랙), 인지 및 사회성 연구단, 기초과학연구원
- 2017 - 교수, IBS-UST
- 2020 - 연구위원, 인지 및 사회성 연구단, 기초과학연구원
수상 실적
- 2014 제주대 우수과학자상
대표 논문
- Kim HJ, Hur SW, Park JB, Seo J, Shi JJ, Kim SY, Kim MH, Han DH, Park JW, Park JM*, Kim SJ*, Chun YS* (2019) Histone demethylase PHF2 activates CREB and promotes memory consolidation. EMBO Rep e45907 (*co-corresponding authors)
- Keum S, Kim A, Shin JJ, Park JM, Shin HS (2018) A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse. Neuron 98:588-601
- Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF (2016) Real-Time Imaging Reveals Properties of Glutamate-Induced Arc.Arg3.1 Translation in Neuronal Dendrites. Neuron 91: 561-573
- Kim HJ, Jeong MH, Kim -R, Jung CY, Lee SY, Kim H, Koh J, Vuong TA, Jung S, Yang H. Park SK, Choi D, Kim SH, Kang K, Sohn JW, Park JM, Jeon D, Koo SH, Ho WK, Kang JS, Kim ST, Cho H (2016) Protein Arginine Methylation Facilitates KCNQ Channel-PIP2 Interaction Leading to Seizure Suppression. eLife 2016;5:e17159
- Shim HG, Jang SS, Jang DC, Jin Y, Chan W, Park JM*, Kim SJ* (2016) mGluR1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol 115:2446-2455 (*co-senior authors)
- Park JM*, Hu JH*, Milshteyn A*, Zhang P, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski K, Kern D, Linden DJ, Worley PF (2013) A Prolyl-isomerase Mediates Dopamine-dependent Plasticity and Cocaine Motor Sensitization. Cell 154(3):637-650 (*equal contribution)
- Das I, Park JM, Shin JH, Jeon SK, Lorenzi H, Linden DJ, Worley PF, Reeves RH (2013) Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Science Translational Medicine 5(201):201ra120
- Hu JH*, Park JM*, Park S*, Xia B, Dehoff MH, Kim S, Hayashi T, Schwarz M, Huganir RL, Seeburg P, Linden DJ, Worley PF (2010) Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 68:1128-1142 (*equal contribution)
- Chang MC, Park JM, Pelkey KA, Granbenstatter HL, Xu D, Linden DJ, Sutula TP, McBain CJ, Worley PF (2010) Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nature Neuroscience 13(9): 1090-1097
- Park S*, Park JM*, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59(1): 70-83 (*equal contribution)
