기초과학연구원 의생명수학그룹
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors. …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Chronotherapeutics- that is administering drugs following the patient's biological rhythms over the 24 h span- may largely impact on both drug toxicities and efficacy in various pathologies including cancer . However, recent findings highlight the critical need of personalizing circadian delivery …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: From fertilization to birth, successful mammalian reproduction relies on interactions of elastic structures with a fluid environment. Sperm flagella must move through cervical mucus to the uterus and into the oviduct, where fertilization occurs. In fact, some sperm may adhere to …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: John Hopfield first pointed out that there are barriers - we call them Hopfield barriers - to biological information-processing at thermodynamic equilibrium. I will explain how the widely-used Hill function with coefficient n is the universal Hopfield barrier to the sharpness …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Simple mathematical models have had remarkable successes in biology, framing how we understand a host of mechanisms and processes. However, with the advent of a host of new experimental technologies, the last ten years has seen an explosion in the amount …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Cells make fate decisions in response to dynamic environments and multicellular structure emerges from interplays among cells in space and time. The recent single-cell genomics technology provides an unprecedented opportunity to profile cells. However, those measurements are taken as snapshots for …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will give an introduction to topological data analysis (TDA), in which one uses ideas from algebraic topology to study the "shape" of data. I will focus on persistent homology (PH), which is the most common approach in TDA.
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: From the venation patterns of leaves to spider webs, roads in cities, social networks, and the spread of COVID-19 infections and vaccinations, the structure of many systems is influenced significantly by space. In this talk, I will discuss the application of …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: We will discuss hormone circuits and their dynamics using new models that take into account timescales of weeks due to growth of the hormone glands. This explains some mysteries in diabetes and autoimmune disease.
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, together with robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: TBA