Papers

Please visit the link at Google Scholar for publications until 2020 [Click Here]

†: co-1st authors, *: co-corresponding authors

Submitted / Preprint

1. Olive R. Cawiding†, Saebom Jeon, Donnabel Tubera-Panes, Aurelio A. de los Reyes V, Jae Kyoung Kim*, Disentangling climate’s dual role in dengue dynamics: a multi-region causal analysis study
   Last update: April 19, 2024
2. Hyukpyo Hong†, Eunjin Eom, Hyojung Lee, Sunhwa Choi, Boseung Choi, Jae Kyoung Kim*, Overcoming Bias in Estimating Epidemiological Parameters: A Bayesian Approach with Realistic History-Dependent Disease Spread Dynamics
   Last update: February 11, 2024
3. Seolah Shin†, Seok Joo Chae†, Seunggyu Lee*, and Jae Kyoung Kim*, Beyond homogeneity: Assessing the validity of the Michaelis–Menten rate law in spatially heterogeneous Environments    
   Last update: January 26, 2024
4. Sunyoung Lee†, Seok Joo Chae†, In-Hwan Jang, Se-Chan Oh, Seok-Min Kim, Soo Yun Lee, Ji Hyun Kim, Jesang Ko, Hang J. Kim, Jae Kyoung Kim* and Tae-Don Kim*, A systematic approach reveals tumor killing activity of NK cells is primarily regulated by activating signals
   Last update: December 25, 2023
5. Yuta Otobe†, Eui Min Jeong†, Shunsuke Ito, Atsu Aiba, Yoshitaka Fukada*, Jae Kyoung Kim* and Hikari Yoshitane*, Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex is essential for mammalian circadian clockwork (Under Review in PNAS)
   Last update: December 25, 2023
6. Gyeong-Im Shin†, Joon-Yung Cha†, Dongju Lim, Aliya Alimzhan, Gyeongik Ahn, Song Yi Jeong, Myung Geun Ji, Sang Yeol Lee, Min Gab Kim, Jeongsik Kim, Jae Kyoung Kim, Woe-Yeon Kim*, GIGANTEA gates TOR-mediated meristem activation to control plant diurnal root growth (Under Review in Science)
   Last update: December 25, 2023
7. Hyeontae Jo†,  Hong Jun Jeon, Junseok Ahn, Saebom Jeon*, Jae Kyoung Kim*,  Seockhoon Chung*, Dysfunctional Beliefs and Attitude about Sleep-6 (DBAS-6): Data-driven Shortened Version from A Machine Learning Approach  
   Last update: December 11, 2023
8. Dongju Lim†, Jaegwon Jeong†, Yun Min Song, Chul-Hyun Cho, Ji Won Yeom, Taek Lee, Jung-Been Lee, Heon-Jeong Lee*, Jae Kyoung Kim*, Highly Accurate Prediction of Mood Episodes in Mood Disorder Patients Using Sleep and Circadian Rhythm Features from Wearables (Under Review in Nature Mental Health)
   Last update: December 25, 2023
9. Yuji Hirono†*, Seokhwan Moon†, Hyukpyo Hong, Jae Kyoung Kim*, Topological Criterion for Robust Perfect Adaptation of Reaction Fluxes in Biological Networks (Under Review in Science Advances)
   arXiv2302.01270Last update: October 23, 2023
10. Song Yi Jeong†, Dae Wook Kim†, Seokmin Ha†, Gyeongik Ahn, Gyeong-Im Shin, Cam Chau Nguyen, Joon-Yung Cha, Jae Kyoung Kim*, Woe-Yeon Kim*, Unraveling strong circadian rhythms: synergy in protein degradation and synthesis
    Last update: September 10, 2023
11. Seunggyu Lee, Yongho Choi, Jaemin Shin, Curvature-based interface restoration algorithm using phase-field equations, submitted  
    Last update: September 20, 2022
12. Haobo Hua, Pu Han, Huan Han, Seunggyu Lee, Junseok Kim, Curvature-dependent area preserving immersed boundary method for binary immiscible fluids, submitted
    Last update: September 20, 2022
13. Seunggyu Lee, Sungha Yoon, Junseok Kim, A linear convex splitting scheme for the Cahn-Hilliard equation with a high-order polynomial free energy, submitted
    Last update: September 20, 2022
14. Seunggyu Lee, Unconditionally strong energy stable scheme for Cahn–Hilliard equation with second-order temporal accuracy, submitted
    Last update: September 20, 2022
15. Jayrah Bena E. Rinon, Renier G. Mendoza, Aurelio A. de los Reyes V, Vicente Y. Belizario Jr., and Victoria May P. Mendoza, Management and control of schistosomiasis in Agusan del Sur, Philippines: A modeling study
    Last update: February 3, 2022

Accepted

16. Jong Hyuk Byun†, Hye Seon Jeon*, Hwi-yeol Yun*, and Jae Kyoung Kim*, Validity Conditions of Approximations for a Target-Mediated Drug Disposition Model: A Novel First-Order Approximation and Its Comparison to Other Approximations (Accepted in PLoS Comput. Biol.)
    Last update: April 11, 2024
17. Hyeontae Jo†, Myna Lim†, Hong Jun Jeon, Junseok Ahn, Saebom Jeon, Jae Kyoung Kim*, Seockhoon Chung*, Data-driven Shortened Insomnia Severity Index: A Machine Learning Approach (Accepted in Sleep and Breathing)
    Last update: April 17, 2024
18. Hyun Kim†, Won Chang, Seok Joo Chae, Jong-Eun Park, Minseok Seo, Jae Kyoung Kim*, scLENS: Data-driven signal detection for unbiased scRNA-seq data analysis (Accepted in Nat. Commun)
    Last update: March 31, 2024

Published

2024

19. Rochelle H. Holm†, Grzegorz A. Rempala†, Boseung Choi†, J. Michael Brick, Alok R. Amraotkar, Rachel J.Keith, EricC.Rouchka, Julia H. Chariker, Kenneth E. Palmer, Ted Smith*, Aruni Bhatnagar*, Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for postvaccine disease burden estimates, communications medicine, 2024
    doi10.1038/s43856-024-00494-yLast update: April 15, 2024
20. Eui Min Jeong†, Jae Kyoung Kim*, Robust Ultrasensitive Transcriptional Switch in Noisy Cellular Environments, npj Systems Biology and Applications, 2024
    doi10.1038/s41540-024-00356-2Last update: March 18, 2024
21. Yun Min Song†, Jaegwon Jeong†, Aurelio V de los Reyes†, Dongju Lim, Chul-Hyun Cho, Ji Won Yeom, Taek Lee, Jung-Been Lee, Heon-Jeong Lee*, and Jae Kyoung Kim*, Causal Dynamics of Sleep, Circadian Rhythm, and Mood in Major Depression and Bipolar Disorder Patients: Insights from Longitudinal Wearable Device Data, eBioMedicine, 2024
    doi10.1016/j.ebiom.2024.105094Last update: April 5, 2024
22. Pan Li*, Jae Kyoung Kim*, Circadian regulation of sinoatrial nodal cell pacemaking function: dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity, PLoS Comput Biol, 2024
    doi10.1371/journal.pcbi.1011907Last update: February 29, 2024
23. Seok Joo Chae†, Dae Wook Kim, Oleg A. Igoshin, Seunggyu Lee and Jae Kyoung Kim*, Beyond microtubule: Cellular environment at the endoplasmic reticulum attracts proteins to the nucleus, essential for nuclear transport, iScience, 2024
    doi10.1016/j.isci.2024.109235Last update: March 18, 2024
24. Yun Min Song†, Sean Campbell†, LieJune Shiau, Jae Kyoung Kim*, William Ott*, Noisy delay denoises biochemical oscillators, Physical Review Letters, 2024
    doi10.1103/PhysRevLett.132.078402Last update: February 16, 2024
25. Minki P. Lee†, Kien Hoang†, Sungkyu Park, Yun Min Song, Eun Yeon Joo, Won Chang^*, Jee Hyun Kim^*, Jae Kyoung Kim^*, Imputing Missing Sleep Data from Wearables with Neural Networks in Real-World Settings, SLEEP, 2024  
    doi10.1093/sleep/zsad266Last update: February 3, 2024

2023

26. Hee Young Kang†, Soo Yun Lee†, Hyun Min Kim†, Su Ui Lee, Hyunseung Lee, Mi Young Cho, Se-Chan Oh, Seok-Min Kim, Hye Sun Park, Eun Hee Han, Seong-Eun Kim, Hyori Kim, Suk Ran Yoon, Junsang Doh, Junho Chung, Kwan Soo Hong*, Inpyo Choi*, Tae-Don Kim*, A modifiable universal cotinine-chimeric antigen system of NK cells with multiple targets, Frontiers in Immunol, 2023
    doi10.3389/fimmu.2022.1089369Last update: December 11, 2023
27. Seok-Min Kim†, Se-Chan Oh, Sun-Young Lee, Ling-Zu Kong, Jong-Hee Lee, Tae-Don Kim*, FTO negatively regulates NK cell killing efficacy, EMBO Rep, 2023
    doi10.15252/embr.202255681Last update: December 11, 2023
28. Dahong Kim†, Seona Jo, Dongjin Lee, Seok-Min Kim, Ji Min Seok, Seon Ju Yeo, Jun Hee Lee, Jae Jong Lee, Kangwon Lee, Tae-Don Kim*, Su A Park*, NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy, Biomaterials Research, 2023
    doi10.1186/s40824-023-00403-9Last update: December 11, 2023
29. Ling-Zu Kong†,  Seok-Min Kim, Chunli Wang, Soo Yun Lee, Se-Chan Oh, Sunyoung Lee, Seona Jo, Tae-Don Kim*, Understanding nucleic acid sensing and its therapeutic applications, Experimental and Molecular Medicine, 2023
    doi10.1038/s12276-023-01118-6Last update: December 11, 2023
30. Hyeontae Jo†, Hyukpyo Hong†, Hyung Ju Hwang, Won Chang, Jae Kyoung Kim*, Density physics-informed neural network reveals sources of cell heterogeneity in signal transduction, Patterns, 2023
    doi10.1016/j.patter.2023.100899Last update: January 1, 2024
31. Yun Min Song†, Su Jung Choi†, Se Ho Park, Soo Jin Lee, Eun Yeon Joo^*, Jae Kyoung Kim^*, A real-time, personalized sleep intervention using mathematical modelling and wearable devices, SLEEP, 2023
    doi10.1093/sleep/zsad179Last update: December 26, 2023
32. Seokmin Ha†, Su Jung Choi†, Sujin Lee, Reinatt Hansel Wijaya, Jee Hyun Kim, Eun Yeon Joo*, Jae Kyoung Kim*, A machine learning-based simple questionnaire for predicting the risk of sleep disorders, J Med Internet Res, 2023
    doi10.2196/46520Last update: September 27, 2023
33. Bryan S Hernandez, Patrick Vincent N. Lubenia, Matthew Johnston, Jae Kyoung Kim, A framework for deriving analytic long-term behavior of biochemical reaction networks, PLoS Computational Biology, 2023
    doi10.1371/journal.pcbi.1011039Last update: December 17, 2023
34. Hyukpyo Hong, Bryan S. Hernandez, Jinsu Kim, Jae Kyoung Kim*, Computational translation framework identifies biochemical reaction networks with special topologies and their long-term dynamics, SIAM Journal on Applied Mathematics, 2023
    doi10.1137/22M150469XLast update: December 17, 2023
35. Se Ho Park, Seokmin Ha, Jae Kyoung Kim*, A general model-based causal inference overcomes the curse of synchrony and indirect effect,  Nature communications, 2023
    doi10.1038/s41467-023-39983-4Last update: December 17, 2023
36. Hyukpyo Hong, Mark Jayson Cortez, Yu-Yu Cheng, Hang Joon Kim, Boseung Choi, Kresimir Josic, and Jae Kyoung Kim, Inferring delays in partially observed gene regulatory networks. Bioinformatics, 2023  
    doi10.1093/bioinformatics/btad670Last update: November 7, 2023
37. Se-Chan Oh, Seong-Eun Kim, In Hwan Jang, Seok-Min Kim, Soo Yun Lee, Sun-Young Lee, In-Sun Chu, Suk Ran Yoon, Haiyoung Jung, Inpyo Choi, Junsang Doh* and Tae-Don Kim*, Nogo receptor 1 is an NK cell inhibitory receptor that destabilizes immunological synapse by regulating actin dynamics, Nature Immunology, 2023  
    doi10.1038/s41590-022-01394-wLast update: December 17, 2023
38. Seok Joo Chae, Dae Wook Kim, Seunggyu Lee, and Jae Kyoung Kim, Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping, iScience, 2023
    doi10.1016/j.isci.2023.106554Last update: December 17, 2023
39. Ngoc-Anh Thi Vu†, Yun Min Song†, Quyen Thi Tran†, Hwi-yeol Yun Sang Kyum Kim*, Jung-woo Chae*, and Jae Kyoung Kim*, Beyond the Michaelis-Menten: Accurate Prediction of Drug Interactions  through Cytochrome P450 Induction, Clinical Pharmacology and Therapeutics, 2023
    doi10.1002/cpt.2824Last update: December 26, 2023
40. Loreniel E. Añonuevo, Zython Paul T. Lachica, Deza A. Amistas, Jayve Iay E. Lato, Hanna Lyka C. Bontilao, Jolly Mae G. Catalan, Rachel Joy F. Pasion, Annabelle P. Yumang, Alexis Erich S. Almocera, Jayrold P. Arcede, May Anne E. Mata, and Aurelio A. de los Reyes V, Transmission dynamics, baseline epidemiological parameter estimates of Coronavirus disease 2019 pre-vaccination: Davao City, Philippines, PLoS ONE, 2023
    doi10.1371/journal.pone.0283068Last update: December 17, 2023
41. Rey Audie S. Escosio, Olive R. Cawiding, Bryan S. Hernandez, Renier G. Mendoza, Victoria May P. Mendoza, Rhudaina Z. Mohammad, Carlene P.C. Pilar-Arceo, Pamela Kim N. Salonga, Fatima Lois E. Suarez, Polly W. Sy, Thomas Herald M. Vergara, and Aurelio A. de los Reyes V, A model-based strategy on COVID-19 vaccine roll-out in the Philippines, Journal of Theoretical Biology, 2023
    doi10.1016/j.jtbi.2023.111596Last update: December 26, 2023
42. Brenda Lyn A. Gavina, Aurelio A. de los Reyes V, Mette S. Olufsen, Suzanne Lenhart, and Johnny T. Ottesen, Toward an optimal contraception dosing strategy, PLoS Computational Biology, 2023
    doi10.1371/journal.pcbi.1010073Last update: December 26, 2023
43. Bryan S. Hernandez and Eduardo R. Mendoza, Weakly reversible CF-decompositions of chemical kinetic systems, Journal of Mathematical Chemistry, 2023
    doi10.1007/s10910-022-01332-zLast update: December 17, 2023
44. Dae Wook Kim†, Ja Min Byun†, Jeong-Ok Lee, Jae Kyoung Kim*, Youngil Koh*, Chemotherapy delivery time affects anti-lymphoma treatment outcome in a sex-dependent manner, JCI insight, 2023
    doi10.1172/jci.insight.164767Last update: December 17, 2023
45. Bryan S. Hernandez and Eduardo R. Mendoza, Positive equilibria of power-law kinetics on networks with independent linkage classes, Journal of Mathematical Chemistry, 2023
    doi10.1007/s10910-022-01432-wLast update: December 17, 2023

2022

46. Seungjun Lee, Boseung Choi, Sung Jae Kim, Jinnam Kim, Dayun Kang, and Jiyoung Lee, Relationship between freshwater harmful algal blooms and neurodegenerative disease incidence rates in South Korea, Environ Health, 2022
    doi10.1186/s12940-022-00935-yLast update: December 18, 2023
47. Seunggyu Lee, Sungha Yoon, Chaeyoung Lee, Sangkwon Kim, Hyundong Kim, Junxiang Yang, Soobin Kwak, Youngjin Hwang, Junseok Kim*, Effective time step for the Allen-Cahn equation with a high-order polynomial free energy, International Journal for Numerical Methods in Engineering, 2022
    doi10.1002/nme.7053Last update: December 17, 2023
48. Ted Smith†, Rochelle H. Holm†, Rachel J. Keith, Alok R. Amraotkar, Chance R. Alvarado, Krzysztof Banecki, Boseung Choi, Ian C. Santisteban, Adrienne M. Bushau-Sprinkle, Kathleen T. Kitterman, Joshua Fuqua, Krystal T. Hamorsky, Kenneth E. Palmer, J. Michael Brick, Grzegorz A. Rempala, Aruni Bhatnagar*, Quantifying the relationship between sub-population wastewater samples and community-wide SARS-CoV-2 seroprevalence, Science of the Total Environment, 2022
    doi10.1016/j.scitotenv.2022.158567Last update: December 17, 2023
49. Seunggyu Lee, Sungha Yoon, and Junseok Kim*, Effective time step analysis of convex splitting for the Swift-Hohenberg equation, Journal of Computational and Applied Mathematics, 2022
    doi10.1016/j.cam.2022.114713Last update: December 17, 2023
50. John J. Tyson, Attila Csikasz-Nagy, Didier Gonze, Jae Kyoung Kim, Silvia Santos, and Jana Wolf, Time-keeping and decision-making in living cells: Part II, Interface Focus, 2022
    doi10.1098/rsfs.2022.0024Last update: December 17, 2023
51. John J. Tyson, Attila Csikasz-Nagy, Didier Gonze, Jae Kyoung Kim, Silvia Santos, and Jana Wolf, Time-keeping and decision-making in living cells: Part I, Interface Focus, 2022
    doi10.1098/rsfs.2022.0011Last update: December 17, 2023
52. Hyo-jeong Ryu†, Won-ho Kang†, Taeheon Kim, Jae Kyoung Kim, Kwang-Hee Shin, Jung-woo Chae*, and Hwi-yeol Yun*, A compatibility evaluation between the physiologically based pharmacokinetic (PBPK) model and the compartmental PK model using the lumping method with real cases , Frontiers in Pharmacology, section Translational Pharmacology, 2022
    doi10.3389/fphar.2022.964049Last update: December 17, 2023
53. Hyukpyo Hong†, Ji Yun Noh†, Hyojung Lee, Sunhwa Choi, Boseung Choi, Jae Kyoung Kim*, Eui-Cheol Shin*, Modeling incorporating the severity-reducing long-term immunity: higher viral transmission paradoxically reduces severe COVID-19 during endemic transition, Immune Network, 2022
    doi10.4110/in.2022.22.e23Last update: December 17, 2023
54. Hyun Kim, Cheolhong Min, Byeongha Jeong, and Kyoung J. Lee, Deciphering clock cell network morphology within the biological master clock, suprachiasmatic nucleus: From the perspective of circadian wave dynamics, PLoS Computational Biology, 2022
    doi10.1371/journal.pcbi.1010213Last update: December 18, 2023
55. Joohee Lee†, Seokmin Ha†, Oli Ahmed, Inn-Kyu Cho, Dongin Lee, Kyumin Kim, Solbi Kang, Sangha Lee, Sooyeon Suh*, Seockhoon Chung*, Jae Kyoung Kim, Validation of a Korean version of the Metacognitions Questionnaire-Insomnia (MCQ-I) and development of shortened versions of the rating scale: a random forest approach, Sleep Medicine, 2022
    doi10.1016/j.sleep.2022.06.005Last update: December 17, 2023
56. Aurelio A. de los Reyes V and Yangjin Kim, Optimal regulation of tumor-associated neutrophils in cancer progression, Royal Society Open Science, 2022
    doi10.1098/rsos.210705Last update: December 17, 2023
57. Eui Min Jeong, Yun Min Song, and Jae Kyoung Kim, Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations, Interface Focus, 2022
    doi10.1098/rsfs.2021.0084Last update: December 18, 2023
58. Miao Lin Paya, Dae Wook Kim, David E. Somers, Jae Kyoung Kim*, Mathias Foo*, Modeling of Plant Circadian Clock for CharacterizingHypocotyl Growth under Different Light QualityConditions, in silico Plants, 2022
    doi10.1093/insilicoplants/diac001Last update: December 17, 2023
59. Yasuko O. Abe, Hikari Yoshitane, Dae Wook Kim, Michinori Koebis, Atsu Aiba, Jae Kyoung Kim*, and Yoshitaka Fukada*, Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals, Nature Communications, 2022
    doi10.1038/s41467-022-32326-9Last update: December 17, 2023
60. Dae Wook Kim†, Hyukpyo Hong†, and Jae Kyoung Kim, Systematic inference identifies a major source of heterogeneity in cell signaling dynamics: the rate-limiting step number, Science Advances, 2022
    doi10.1126/sciadv.abl4598Last update: December 17, 2023
61. Eui Min Jeong†, Miri Kwon†, Eunjoo Cho†, Sang Hyuk Lee, Hyun Kim, Eun Young Kim*, and Jae Kyoung Kim*, Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons, Proceedings of the National Academy of Science, 2022
    doi10.1073/pnas.2113403119Last update: December 17, 2023

2021

62. Jaewoo Park, Won Chang, Boseung Choi, An Interaction Neyman-Scott Point Process Model for Coronavirus Disease-19, Spatial Statistics, 2021
    doi10.1016/j.spasta.2021.100561Last update: December 17, 2023
63. Seunggyu Lee, Non-iterative compact operator splitting scheme for Allen–Cahn equation, Computational & Applied Mathematics, 2021
    doi10.1007/s40314-021-01648-7Last update: December 17, 2023
64. Mi-Sun Hur, Seunggyu Lee, Tong Mook Kang, and Chang-Seok Oh, The three muscle layers in the pyloric sphincter and their possible function during antropyloroduodenal motility, Scientific Reports, 2021
    doi10.1038/s41598-021-99463-xLast update: December 17, 2023
65. Jae Kyoung Kim. Tick, Tock, Circadian Clocks. In Pavel Kraikivski (Ed.) Case Studies in Systems Biology (pp. 48-64). Springer International Publishing, 2021
    doi10.1007/978-3-030-67742-8Last update: December 17, 2023
66. Hyukpyo Hong, Boseung Choi, Jae Kyoung Kim, Beyond the Michaelis–Menten: Bayesian Inference for Enzyme Kinetic Analysis. In Quentin Vanhaelen (Ed.) Computational Methods for Estimating the Kinetic Parameters of Biological Systems, Springer US, 2021
    doi10.1007/978-1-0716-1767-0_3Last update: December 17, 2023
67. Mark Jayson Cortez, Hyukpyo Hong, Boseung Choi*, Jae Kyoung Kim*, and Krešimir Josic*, Hierarchical Bayesian models of transcriptional and translational regulation processes with delays, Bioinformatics, 2021
    doi10.1093/bioinformatics/btab618Last update: December 17, 2023
68. Youri G. Bolsius, Matias D. Zurbriggen, Jae Kyoung Kim, Martien J.Kas, Peter Meerlo, Sara J.Aton, and Robbert Havekes, The role of clock genes in sleep, stress and memory, Biochemical Pharmacology, 2021
    doi10.1016/j.bcp.2021.114493Last update: December 17, 2023
69. Yun Min Song†, Hyukpyo Hong†, and Jae Kyoung Kim,  Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities, PLoS Computational Biology, 2021
    doi10.1371/journal.pcbi.1008952Last update: December 17, 2023
70. Hyukpyo Hong†, Jinsu Kim†, M Ali Al-Radhawi, Eduardo Sontag, and Jae Kyoung Kim,  Derivation of stationary distributions of biochemical reaction networks via structure transformation, Communications Biology, 2021
    doi10.1038/s42003-021-02117-xLast update: December 17, 2023
71. Jonathan Tyler, Daniel Forger, and Jae Kyoung Kim, Inferring causality in biological oscillators, Bioinformatics, 2021
    doi10.1093/bioinformatics/btab623Last update: December 17, 2023
72. Jaehyoung Hong†, Su Jung Choi†, Se Ho Park, Hyukpyo Hong, Victoria Booth, Eun Yeon Joo*, and Jae Kyoung Kim*, Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness, iScience, 2021
    doi10.1016/j.isci.2021.103129Last update: December 17, 2023