We will discuss about Moderate activity of RNA chaperone maximizes the yield of self-spliced pre-RNA in vivo”, Song, Yonghyun, D. Thirumalai, and Changbong Hyeon, bioRxiv (2022). Abstract CYT-19 is a DEAD-box protein whose ATP-dependent helicase activity facilitates the folding of group I introns in precursor RNA (pre-RNA) of Neurospora crassa. In the process they consume a …

We will discuss about “Optimal control of aging in complex networks”, Sun, Eric D., Thomas CT Michaels, and L. Mahadevan, Proceedings of the National Academy of Sciences 117.34 (2020): 20404-20410. Abstract Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question …

We will discuss about “Analytical time-dependent distributions for gene expression models with complex promoter switching mechanisms”,Jia, Chen, and Youming Li, BioRxiv (2022). Abstract Classical gene expression models assume exponential switching time distributions between the active and inactive promoter states. However, recent experiments have shown that many genes in mammalian cells may produce non-exponential switching time …