A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells

B305 Seminar room, IBS 55 Expo-ro Yuseong-guDaejeon,

We will discuss about “A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells”, Unosson et al., bioRxiv, 2021 We propose a stochastic distributed delay model together with a Markov random field prior and a measurement model for bioluminescence-reporting to analyse spatiotemporal gene expression in intact

A temporal signaling code to specify immune responses

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors.

Balanced truncation for model reduction of biological oscillators

B305 Seminar room, IBS 55 Expo-ro Yuseong-guDaejeon,

We will discuss about “Balanced truncation for model reduction of biological oscillators”, Padoan et al., Biological Cybernetics, 2021 Model reduction is a central problem in mathematical biology. Reduced order models enable modeling of a biological system at different levels of complexity and the quantitative analysis of its properties, like sensitivity to parameter variations and resilience

Systems pharmacology towards personalized chronotherapy

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Chronotherapeutics- that is administering drugs following the patient's biological rhythms over the 24 h span- may largely impact on both drug toxicities and efficacy in various pathologies including cancer . However, recent findings highlight the critical need of personalizing circadian delivery

Scaling in development

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract:  Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration

Biofluiddynamics of reproduction

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: From fertilization to birth, successful mammalian reproduction relies on interactions of elastic structures with a fluid environment. Sperm flagella must move through cervical mucus to the uterus and into the oviduct, where fertilization occurs. In fact, some sperm may adhere to

Quantitative comparisons between models and data to provide new insights in cell and developmental biology

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Simple mathematical models have had remarkable successes in biology, framing how we understand a host of mechanisms and processes. However, with the advent of a host of new experimental technologies, the last ten years has seen an explosion in the amount

IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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