Eui Min Jeong, Phenotypic switching in gene regulatory networks

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

We will discuss about "Phenotypic switching in gene regulatory networks", PNAS (2014).   Abstract Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that the abundance distributions of proteins in a population of isogenic cells may display multiple distinct maxima. Each of these maxima may be associated with a

Yun Min Song, Pathspace Kalman Filters with Dynamic Process Uncertainty for Analyzing Time-course Data

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

We will discuss about "Pathspace Kalman Filters with Dynamic Process Uncertainty for Analyzing Time-course Data", ArXiv (2024).   Abstract Kalman Filter (KF) is an optimal linear state prediction algorithm, with applications in fields as diverse as engineering, economics, robotics, and space exploration. Here, we develop an extension of the KF, called a Pathspace Kalman Filter

Jingyi Jessica Li, ClusterDE: a post-clustering differential expression (DE) method robust to false-positive inflation caused by double dipping

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find discrete cell clusters as putative cell types, and then a statistical test is employed to identify the differentially expressed (DE) genes between the cell clusters. However, this common procedure suffers the ``double dipping'' issue: the same data are used twice

Timothy L. Downing, Biophysical Regulation of Cell Fate, from ECM to Nuclear Chromatin

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Abstract: The Downing lab investigates the intricate biophysical interactions between cells and their environment, elucidating their role in modulating adult cell behavior and phenotypic transitions via epigenetic regulation of gene expression. Leveraging diverse genome-scale sequencing techniques, we decipher mechanisms underlying cell fate transitions mediated through dynamic regulation of nuclear chromatin and heterogeneous gene activity. Our

Recent Advances in Methods for Biomedical Mathematics

IBS Science Culture Center Expo-ro 55, Daejeon, Korea, Republic of

This satellite workshop for 2024 SMB-KSMB Annual Meeting will be held at IBS in Daejeon, conveniently located about an hour from Seoul by train or approximately three hours from Incheon airport by bus. We're planning a comprehensive program, featuring six instructive tutorials, each lasting two hours. These sessions will cover various methodologies pivotal to our

IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
Copyright © IBS 2021. All rights reserved.