Brian P. Delisle, Circadian Regulation of Cardiac Electrophysiology
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)Abstract: TBD
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We will discuss about "Phenotypic switching in gene regulatory networks", PNAS (2014). Abstract Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that the abundance distributions of proteins in a population of isogenic cells may display multiple distinct maxima. Each of these maxima may be associated with a …
We will discuss about "Pathspace Kalman Filters with Dynamic Process Uncertainty for Analyzing Time-course Data", ArXiv (2024). Abstract Kalman Filter (KF) is an optimal linear state prediction algorithm, with applications in fields as diverse as engineering, economics, robotics, and space exploration. Here, we develop an extension of the KF, called a Pathspace Kalman Filter …
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Abstract: In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find discrete cell clusters as putative cell types, and then a statistical test is employed to identify the differentially expressed (DE) genes between the cell clusters. However, this common procedure suffers the ``double dipping'' issue: the same data are used twice …
Abstract: The Downing lab investigates the intricate biophysical interactions between cells and their environment, elucidating their role in modulating adult cell behavior and phenotypic transitions via epigenetic regulation of gene expression. Leveraging diverse genome-scale sequencing techniques, we decipher mechanisms underlying cell fate transitions mediated through dynamic regulation of nuclear chromatin and heterogeneous gene activity. Our …
This satellite workshop for 2024 SMB-KSMB Annual Meeting will be held at IBS in Daejeon, conveniently located about an hour from Seoul by train or approximately three hours from Incheon airport by bus. We're planning a comprehensive program, featuring six instructive tutorials, each lasting two hours. These sessions will cover various methodologies pivotal to our …