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Spatiotemporal reconstruction of static single-cell genomics data

March 3 @ 11:00 am - 12:00 pm KST

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium), (pw: 1234)

Speaker

Qing Nie
University of California, Irvine
https://faculty.sites.uci.edu/qnie/

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234)

Abstract: Cells make fate decisions in response to dynamic environments and multicellular structure emerges from interplays among cells in space and time. The recent single-cell genomics technology provides an unprecedented opportunity to profile cells. However, those measurements are taken as snapshots for groups of individual cells with only static information. Can one infer interactions among cells from such datasets? Is it possible to recover spatial information from non-spatial datasets? How to obtain temporal relationships of cells from the static measurements? In this talk I will present our newly developed computational tools that reconstruct interactions and spatiotemporal relationships for cells using single-cell RNA-seq, ATAC-seq, and spatial transcriptomics datasets. Through applications of those methods to systems in development and regeneration, we show the discovery power of such methods and identify areas for further development in spatiotemporal reconstruction.

Details

Date:
March 3
Time:
11:00 am - 12:00 pm KST
Event Category:

Venue

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)
(pw: 1234)

Organizer

Jae Kyoung Kim
Email:
jaekkim@kaist.ac.kr
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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