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Universal biology in adaptation and evolution: dimensional reduction, and fluctuation-response relationship

April 7, 2022 @ 11:00 am - 12:00 pm KST

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium), (pw: 1234)

Speaker

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234)

Abstract: A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, together with robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular states is derived, as is confirmed by adaptation experiments of bacteria under stress. The theory is extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and by environmental adaptation, which explains the evolutionary fluctuation-response relationship previously uncovered.  

References

  1. Kaneko K., Life: An Introduction to Complex Systems Biology, Springer (2006)
  2. K. Kaneko, C.Furusawa, T. Yomo, “Macroscopic phenomenology for cells in steady-growth state”, Phys.Rev.X(2015) 011014
  3. C. Furusawa, K. Kaneko “Global Relationships in Fluctuation and Response in Adaptive Evolution”, J of Royal Society Interface 12(2015), 20150482.
  4. C. Furusawa, K. Kaneko ” Formation of Dominant Mode by Evolution in Biological Systems” Phys. Rev. E 97(2018)042410
  5. K. Kaneko, C. Furusawa “Macroscopic Theory for Evolving Biological Systems Akin to Thermodynamics”, Annual Rev. Biophys. (2018) 47, 273-290
  6. A. Sakata and K. Kaneko, “Dimensional Reduction in Evolving Spin-Glass Model: Correlation of Phenotypic Responses to Environmental and Mutational Changes”, Phys. Rev. Lett. (2020) 124, 218101
  7. Q-Y. Tang and K. Kaneko, “ Dynamics-evolution correspondence in protein structures”,  Phys. Rev. Lett. (2021) 127, 098103

Details

Date:
April 7, 2022
Time:
11:00 am - 12:00 pm KST
Event Category:

Venue

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)
(pw: 1234)

Organizer

Jae Kyoung Kim
Email
jaekkim@kaist.ac.kr
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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