Biomedical Mathematics Online Colloquium

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, together with robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: TBA

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at least six months. There are a number of complicating factors …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Outputs from health biological systems display complex fluctuations that are not random but display robust and often self-similar (fractal) temporal correlations at different time scales— scaling behaviors. The scaling behaviors in the fluctuations of biological outputs such as neural activities, cardiac …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: The idea of balance between excitation and inhibition is central in the theory of biological neural networks.  I will give a brief introduction to the concept of such balance, and an overview of the mathematical ideas that can be used to study …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will first describe how to extend the theory of balanced networks to account for synaptic plasticity. This theory can be used to show when a plastic network will maintain balance, and when it will be driven into an unbalanced state. …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will introduce mathematical and computational methods for spatio-temporal modelling in molecular and cell biology, including all-atom and coarse-grained molecular dynamics (MD), Brownian dynamics (BD), stochastic reaction-diffusion models and macroscopic mean-field equations. Microscopic (BD, MD) models are based on the simulation …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will discuss the development, analysis and applications of multi-resolution methods for spatio-temporal modelling of intracellular processes, which use (detailed) Brownian dynamics or molecular dynamics simulations in localized regions of particular interest (in which accuracy and microscopic details are important) and …

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Quantitative characterization of biomolecular networks is important for the analysis and design of network functionality. Reliable models of such networks need to account for intrinsic and extrinsic noise present in the cellular environment. Stochastic kinetic models provide a principled framework for …