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A systems biology approach using multi-scale modeling to understand the immune response to tuberculosis infection and treatment

April 14, 2022 @ 11:00 am - 12:00 pm KST

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium), (pw: 1234)

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234)

Abstract: Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at least six months. There are a number of complicating factors that contribute to the need for this long treatment duration and increase the risk of treatment failure. The structure of granulomas, lesions forming in lungs in response to Mtb infection, create heterogeneous antibiotic distributions that limit antibiotic exposure to Mtb.   We can use a systems biology approach pairing experimental data from non-human primates with computational modeling to represent and predict how factors impact antibiotic regimen efficacy and granuloma bacterial sterilization. We utilize an agent-based, computational model that simulates granuloma formation, function and treatment, called GranSim.  A goal in improving antibiotic treatment for TB is to find regimens that can shorten the time it takes to sterilize granulomas while minimizing the amount of antibiotic required. We also created a whole host model, called HOSTSIM, to study Mtb dynamics within a human host.  Overall, we use these models to help better understand TB treatment and strengthen our ability to predict regimens that can improve clinical treatment of TB.

Details

Date:
April 14, 2022
Time:
11:00 am - 12:00 pm KST
Event Category:

Venue

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)
(pw: 1234)

Organizer

Jae Kyoung Kim
Email
jaekkim@kaist.ac.kr
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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