기초과학연구원 의생명수학그룹
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: John Hopfield first pointed out that there are barriers - we call them Hopfield barriers - to biological information-processing at thermodynamic equilibrium. I will explain how the widely-used Hill function with coefficient n is the universal Hopfield barrier to the sharpness …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Simple mathematical models have had remarkable successes in biology, framing how we understand a host of mechanisms and processes. However, with the advent of a host of new experimental technologies, the last ten years has seen an explosion in the amount …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Cells make fate decisions in response to dynamic environments and multicellular structure emerges from interplays among cells in space and time. The recent single-cell genomics technology provides an unprecedented opportunity to profile cells. However, those measurements are taken as snapshots for …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will give an introduction to topological data analysis (TDA), in which one uses ideas from algebraic topology to study the "shape" of data. I will focus on persistent homology (PH), which is the most common approach in TDA.
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: From the venation patterns of leaves to spider webs, roads in cities, social networks, and the spread of COVID-19 infections and vaccinations, the structure of many systems is influenced significantly by space. In this talk, I will discuss the application of …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: We will discuss hormone circuits and their dynamics using new models that take into account timescales of weeks due to growth of the hormone glands. This explains some mysteries in diabetes and autoimmune disease.
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, together with robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: TBA
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at least six months. There are a number of complicating factors …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Outputs from health biological systems display complex fluctuations that are not random but display robust and often self-similar (fractal) temporal correlations at different time scales— scaling behaviors. The scaling behaviors in the fluctuations of biological outputs such as neural activities, cardiac …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: The idea of balance between excitation and inhibition is central in the theory of biological neural networks. I will give a brief introduction to the concept of such balance, and an overview of the mathematical ideas that can be used to study …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will first describe how to extend the theory of balanced networks to account for synaptic plasticity. This theory can be used to show when a plastic network will maintain balance, and when it will be driven into an unbalanced state. …
