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Brain dynamics during shiftwork: from maths and codes to real-world applications
November 30, 2022 @ 4:00 pm - 5:00 pm KST
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium),
(pw: 1234)
Abstract:
Circadian clocks control the timing and 24-hour periodicity of virtually all physiological rhythms including sleep, cognition, and metabolism. There are optimal times for most behaviours; e.g., the best sleep is achieved during low circadian activity (night), while meals and physical exercise are best placed during high circadian activity (day) when metabolic rates, stress hormone levels, and blood pressure are higher. However, the demands of our 24/7 society often result in misalignment of these environmental, behavioural and physiological rhythms with the typical examples being shiftwork, jetlag, and circadian disorders. This circadian misalignment results in inadequate sleep, fatigue, increased risk of accidents, and in the long-term, development of disease including cancer and diabetes. Mathematical modelling of circadian misalignment is used to better understand the circadian and sleep regulation and make predictions to reduce risk of fatigue-related accidents. In this talk I will present an overview of our studies of shiftwork modelling and our journey from fundamental modelling research of sleep and circadian rhythms to development of software tools and real-world applications.