기초과학연구원 의생명수학그룹
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: The idea of balance between excitation and inhibition is central in the theory of biological neural networks. I will give a brief introduction to the concept of such balance, and an overview of the mathematical ideas that can be used to study …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will first describe how to extend the theory of balanced networks to account for synaptic plasticity. This theory can be used to show when a plastic network will maintain balance, and when it will be driven into an unbalanced state. …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will introduce mathematical and computational methods for spatio-temporal modelling in molecular and cell biology, including all-atom and coarse-grained molecular dynamics (MD), Brownian dynamics (BD), stochastic reaction-diffusion models and macroscopic mean-field equations. Microscopic (BD, MD) models are based on the simulation …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will discuss the development, analysis and applications of multi-resolution methods for spatio-temporal modelling of intracellular processes, which use (detailed) Brownian dynamics or molecular dynamics simulations in localized regions of particular interest (in which accuracy and microscopic details are important) and …
This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Quantitative characterization of biomolecular networks is important for the analysis and design of network functionality. Reliable models of such networks need to account for intrinsic and extrinsic noise present in the cellular environment. Stochastic kinetic models provide a principled framework for …
Abstract: The activation of Ras depends upon the translocation of its guanine nucleotide exchange factor, Sos, to the plasma membrane. Moreover, artificially inducing Sos to translocate to the plasma membrane is sufficient to bring about Ras activation and activation of Ras’s targets. There are many other examples of signaling proteins that must translocate to the …
Abstract: The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology, but this ambition is - paradoxically - limited by the very wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under …
Abstract: Cell growth, DNA replication, mitosis and division are the fundamental processes by which life is passed on from one generation of eukaryotic cells to the next. The eukaryotic cell cycle is intrinsically a periodic process but not so much a ‘clock’ as a ‘copy machine’, making new daughter cells as warranted. Cells growing under …
Abstract: TBA
Abstract: Cellular, chemical, and population processes are all often represented via networks that describe the interactions between the different population types (typically called the "species"). If the counts of the species are low, then these systems are often modeled as continuous-time Markov chains on the d-dimensional integer lattice (with d being the number of species), …
Abstract: We’re all familiar with sleep, but how can we mathematically model it? And what determines how long and when we sleep? In this talk I’ll introduce the nonsmooth coupled oscillator systems that form the basis of current models of sleep-wake regulation and discuss their dynamical behaviour. I will describe how we are using models …
Cells make individual fate decisions through linear and nonlinear regulation of gene network, generating diverse dynamics from a single reaction pathway. In this colloquium, I will present two topics of our recent work on signaling dynamics at cellular and patient levels. The first example is about the initial value of the model, as a mechanism …