기초과학연구원 의생명수학그룹
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Non-Markov models of stochastic biochemical kinetics often incorporate explicit time delays to effectively model large numbers of intermediate biochemical processes. Analysis and simulation of these models, as well as the inference of their parameters from data, are fraught with difficulties because …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Accurate assessment of circadian timing is critical to many applications, including timing of drug delivery, prediction of neurobehavioral performance, and optimized scheduling of sleep. Current methods for measuring circadian timing are onerous and do not produce results in real time. Mathematical …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Organisms have evolved an internal biological clock which allows them to temporally regulate and organize their physiological and behavioral responses to cope in an optimal way with the fundamentally periodic nature of the environment. It is now well established that the …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Homeostasis is a recurring theme in biology that ensures that regulated variables robustly adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control, a negative feedback strategy that performs mathematical integration to achieve …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Our current approach to cancer treatment has been largely driven by finding molecular targets, those patients fortunate enough to have a targetable mutation will receive a fixed treatment schedule designed to deliver the maximum tolerated dose (MTD). These therapies generally achieve …
CANCELED due to unexpected circumstances This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: While the presence of immune cells within solid tumours was initially viewed positively, as the host fighting to rid itself of a foreign body, we now know that the tumour can manipulate immune cells so that …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Questions about the mechanistic operation of biological systems are naturally formulated as stochastic processes, but confronting such models with data can be challenging. In this talk, I describe the essence of the difficulty, highlighting both the technical issues and the importance …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors. …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Chronotherapeutics- that is administering drugs following the patient's biological rhythms over the 24 h span- may largely impact on both drug toxicities and efficacy in various pathologies including cancer . However, recent findings highlight the critical need of personalizing circadian delivery …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: From fertilization to birth, successful mammalian reproduction relies on interactions of elastic structures with a fluid environment. Sperm flagella must move through cervical mucus to the uterus and into the oviduct, where fertilization occurs. In fact, some sperm may adhere to …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: John Hopfield first pointed out that there are barriers - we call them Hopfield barriers - to biological information-processing at thermodynamic equilibrium. I will explain how the widely-used Hill function with coefficient n is the universal Hopfield barrier to the sharpness …