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Theory and design of molecular integral feedback controllers

July 28 @ 5:00 pm - 6:00 pm KST

ZOOM ID: 709 120 4849 (ibsbimag)
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234)
Abstract:

Homeostasis is a recurring theme in biology that ensures that regulated variables robustly adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control, a negative feedback strategy that performs mathematical integration to achieve structurally robust regulation. Despite its benefits, the synthetic realization of integral feedback in living cells has remained elusive owing to the complexity of the required biological computations. In this talk I will show that there is a single fundamental biomolecular controller topology that realizes integral feedback and achieves robust perfect adaptation in arbitrary intracellular networks with noisy dynamics. This adaptation property is guaranteed both for the population-average and for the time-average of single cells. On the basis of this concept, I will describe a genetically engineered synthetic integral feedback controller in living cells and demonstrate its tunability and adaptation properties. A growth-rate control application in Escherichia coli shows the intrinsic capacity of our integral controller to deliver robustness and highlights its potential use as a versatile controller for regulation of biological variables in uncertain networks. These results provide conceptual and practical tools in the area of cybergenetics, for engineering synthetic controllers that steer the dynamics of living systems.

Details

Date:
July 28
Time:
5:00 pm - 6:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email:
jaekkim@kaist.ac.kr

Venue

ZOOM ID: 709 120 4849 (ibsbimag)
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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