기초과학연구원 의생명수학그룹
Abstract: Circadian clocks control the timing and 24-hour periodicity of virtually all physiological rhythms including sleep, cognition, and metabolism. There are optimal times for most behaviours; e.g., the best sleep …
Abstract: The ability to reliably engineer the mammalian cell will impact a variety of applications in a disruptive way, including cell fate control and reprogramming, targeted drug delivery, and regenerative …
We will discuss about “Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors”, Vipond, Oliver, et al, Proceedings of the National Academy of Sciences 118.41 (2021): e2102166118. Abstract …
Abstract: Since before the time of Aristotle and the natural philosophers, reductionism has played a foundational role in western scientific thought. The premise of reductionism is that systems can be …
Absolute Concentration Robustness (ACR) was introduced by Shinar and Feinberg (Science 327:1389-1391, 2010) as robustness of equilibrium species concentration in a mass action dynamical system. Their aim was to devise a mathematical …
We will discuss about "Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators”, Karapetyan, Sargis, and Nicolas E. Buchler,Physical Review E 92.6 (2015): 062712. Abstract Genetic oscillators, …
We will discuss about “Optimal control of aging in complex networks”, Sun, Eric D., Thomas CT Michaels, and L. Mahadevan, Proceedings of the National Academy of Sciences 117.34 (2020): 20404-20410. Abstract …
사람이 어떻게 만들어지고 각 기관이 어떻게 발달하는지에 대한 질문은 아주 오래전부터 있었습니다. 체외수정(IVF)의 고유의 장점으로 인해 과학자들이 수정란을 외부에서 관찰할 수 있게 되었습니다. 하지만, 1979년도에 제정된 14일 규정(the 14-day rule)으로 …
We will discuss about “Analytical time-dependent distributions for gene expression models with complex promoter switching mechanisms”,Jia, Chen, and Youming Li, BioRxiv (2022). Abstract Classical gene expression models assume exponential switching …
We will discuss about “Bayesian Physics Informed Neural Networks for real-world nonlinear dynamical systems”, Linka, Kevin, et al., Computer Methods in Applied Mechanics and Engineering Volume 402, 1 December 2022, 115346 …
We will discuss about “Topological Data Analysis in Time Series: Temporal Filtration and Application to Single-Cell Genomics" , Lin, Baihan., arXiv preprint arXiv:2204.14048 (2022). Abstract The absence of a conventional association …
Complexity of the cellular organization of the tumor microenvironment as an ecosystem remains to be fully appreciated. Here, for a comprehensive investigation of tumor ecosystems across a wide variety of …