Abstract: This talk consists of two main parts. In the first part, I will discuss a numerical method for solving PDEs based on a stochastic representation of the solution. This approach captures the underlying particle dynamics associated with the physical processes described by the PDE. By aggregating information from the particles’ collective exploration, the method …

Abstract: Weight calibration is a popular technique in handling covariate-shift problem in causal inference. It can be viewed as a dual optimization problem for incorporating the implicit regression model. We introduce the generalized entropy calibration as a general tool for weight calibration. Several interesting applications will be introduced in the context of causal inference. Furthermore, weight calibration can be used to transfer learning, which combines information from two different samples, one for source data and the other for target data.

Abstract  Topological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional, complex datasets. In this talk, we present two applications of TDA in analyzing patterns, one in the tumor microenvironment (TME) and the other in high-resolution chemical profiling. In the first case, we develop a TDA-based framework to quantify malignant-immune cell interactions …

Abstract Background : Excess mortality captures both the direct and indirect impacts of the pandemic. We examine (1) within-country heterogeneity by healthcare access over distinct viral waves in Korea, and (2) cross-country associations between excess mortality and preparedness (Global Health Security, GHS), stratified by IMF development stage. Methods : Study 1 assembled a region-level panel …

본 발표는 삼성에서 개발 중인 디지털 헬스케어 기술을 소개합니다. 먼저, 삼성 갤럭시 웨어러블 센서의 기능과 활용 가능성을 설명하며, 웰니스 및 의료기기 서비스의 상품화 사례를 소개합니다. 또한, 삼성이 디지털 헬스케어를 통해 추구하는 방향과 비전을 제시합니다. 마지막으로, 삼성 개발자로서 디지털 헬스케어의 미래 전망과 기술 발전 가능성에 대해 논의합니다. 이를 통해 디지털 헬스케어가 개인 건강 관리와 의료 산업에 …

Digital health leverages information and communication technologies to transform healthcare, enabling diverse solutions for continuous health management. Among these, wearable-based digital health plays a key role by collecting, monitoring, and analyzing physiological data over extended periods. In this lecture, I will introduce the sleep-related features of Samsung’s Galaxy Watch series, focusing on the biosignals that …

Abstract Recent emergence and re-emergence of infectious disease pathogens have caused major disruptions to our society, highlighting the importance of managing ongoing outbreaks and predicting future epidemics. In this talk, I will use mathematical models to test biological hypotheses about pathogen transmission and leverage these findings to inform public health guidance. I will begin by …

This seminar examines how generative AI advances three foundational tasks in causality, treated as distinct, modular problems: (1) causal inference via intervention‑effect estimation, (2) causal graph analysis, and (3) detection of causal mechanism shifts and change points. First, for causal inference, we consider procedures in which generative models align domain knowledge with observational signals to …

Classical machine learning models are typically trained under the assumption that the training (source) and test (target) data are drawn from the same distribution. However, real-world data are rarely clean or consistent, and distribution shifts between the source and target domains are ubiquitous. Despite its importance, addressing distribution shifts is highly difficult. The fundamental challenge …

Recent advances in data science have expanded the scope of data analysis beyond prediction accuracy toward interpretability, causal understanding, and generalizable learning across complex data structures. This lecture introduces three emerging methodological approaches that can be directly leveraged in modern data analysis workflows. First, the lecture presents explainable artificial intelligence (XAI) techniques, focusing on SHAP …

Mathematical modeling provides essential quantitative insights that accelerate drug and cell therapy development. In this presentation, we utilize kinetic frameworks to optimize the design of molecular glues by elucidating their biophysical determinants and identify a key target for NK cell-mediated immunotherapy through systematic data analysis. Collectively, we demonstrate how mathematical strategies can effectively guide and …

Complex diseases, such as cancer, sarcopenia, and immune disorders, arise from abnormalities in multiple genes and pathways, posing significant challenges to conventional single-target drug discovery strategies. To address this, we developed a perturbome-based analytical framework that integrates transcriptomic signatures, network pharmacology, and machine learning to identify effective therapeutic candidates. Central to this approach is the …