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Biomedical Mathematics Seminar
Jonathan Rubin, Qualitative inverse problems: mapping from limited data to properties of dynamics and parameter values for ODE models
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of
Hyung Jin Choi, A Normative Framework Dissociates Need and Motivation in Hypothalamic Neurons
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofAbstract: Physiological needs evoke motivational drives to produce natural behaviours for survival. However, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components in previous experimental paradigms. Based on classic homeostatic theories, we established a normative framework to derive computational models of neural activity and behaviours for need-encoding …
Junil Kim, TENET+: a tool for reconstructing gene networks by integrating single cell expression and chromatin accessibility data
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofAbstract: Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation …
Jong Kyoung Kim, Dissecting cellular heterogeneity and plasticity in adipose tissue
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofAbstract: Cell-to-cell variability in gene expression exists even in a homogeneous population of cells. Dissecting such cellular heterogeneity within a biological system is a prerequisite for understanding how a biological system is developed, homeostatically regulated, and responds to external perturbations. Single-cell RNA sequencing (scRNA-seq) allows the quantitative and unbiased characterization of cellular heterogeneity by providing …
Kang MIn Lee, Oscillation in brain and its potential role in inter-areal communication
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofAbstract: Through the past decades, electrophysiological experiments have revealed that extracellular electrical potential of brain show diverse rhythmic activity. Called ‘Local Field Potential(LFP)’, those rhythmic activities are thought to reflect populational activity of neurons. In this talk, I will introduce basic concepts on LFP and its generation mechanisms. Then, roles of LFP in brain inter-areal …
Timothy L. Downing, Biophysical Regulation of Cell Fate, from ECM to Nuclear Chromatin
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofAbstract: The Downing lab investigates the intricate biophysical interactions between cells and their environment, elucidating their role in modulating adult cell behavior and phenotypic transitions via epigenetic regulation of gene expression. Leveraging diverse genome-scale sequencing techniques, we decipher mechanisms underlying cell fate transitions mediated through dynamic regulation of nuclear chromatin and heterogeneous gene activity. Our …
Hyungsuk Tak, Statistical Challenges in Astronomical Time Delay Estimation (Cancelled)
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofI present time delay estimation problems in astronomy as a part of time delay cosmography to infer the Hubble constant, the current expansion rate of the Universe. Time delay cosmography is based on strong gravitational lensing, an effect that multiple images of the same astronomical object appear in the sky because paths of the light …
Summer Intern workshop 2024
Presentor(s) Mentor Talk title Jaehun Jeong Gyuyoung Hwang Analyzing coupled SCN cell frequencies of mammals for multi-step transcriptional model Hyunsuk Choo, Yonghee Lee Seok Joo Chae Development of a data-driven causality detection method using Taken's Theorem Juhyeon Kim Dongju Lim Accurate initial condition for circadian pacemaker model estimating the circadian phase Kyeongtae Ko Dongju …
Hyukpyo Hong, Koopman representation: Linear representation – not an approximation – of nonlinear dynamics
Abstract: A system of ordinary differential equations (ODEs) is one of the most widely used tools to describe a deterministic dynamical system. In general, such ODEs involve nonlinear equations, which make analysis of dynamical systems difficult. In this talk, we introduce Koopman theory, which offers a linear representation – not an approximation – of nonlinear dynamics. In particular, we present a data-driven algorithm to find such a linear representation
Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)Abstract: Wearable biosensors measure physiological variables with high temporal resolution over multiple days and are increasingly employed in clinical settings, such as continuous glucose monitoring in diabetes care. Such datasets bring new opportunities and challenges, and patients, clinicians, and researchers are today faced with a common challenge: how to best summarize and capture relevant information …
Make Your Science Friendly: A Guide to Engaging Visuals – Sunghwan Bae
B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic ofThe talk will be hybrid, participants may join via Zoom with the following link: https://us06web.zoom.us/j/99567630778?pwd=N2ZrUWtqZzJ0YURVTzlZT3JJR3FUQT09