Design frameworks for engineering efficient cell factory performance within host and industrial constraints

This talk will be given online. Abstract: Synthetic biology and microbial biotechnology offer sustainable routes to the manufacture of commodity and high value chemicals from agricultural by-products instead of petrochemical feedstocks. However, engineered gene circuits and metabolic pathways both co-opt the cell’s gene expression machinery for protein/enzyme production and divert metabolic flux away from key

Causal Inference – basics and examples

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Abstract: In real world, people are interested in causality rather than association. For example, pharmaceutical companies want to know effectiveness of their new drugs against diseases. South Korea Government officials are concerned about the effects of recent regulation with respect to an electric car subsidy from United States. Due to this reason, causal inference has

Shift: A mobile application for shift workers leveraging wearable data, mathematical models, and connected devices

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Shift workers experience profound circadian disruption due to the nature of their work, which often has them working at times when their internal clock is sending a strong signal for sleep. Mathematical models can be used to generate recommendations for shift workers that shift their body's clock to better align with their work schedules, to

Developing and designing dynamic mobile applications that transform wearable data with machine learning and mathematical models.

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Wearable analytics hold far more potential than sleep tracking or step counting. In recent years, a number of applications have emerged which leverage the massive quantities of data being amassed by wearables around the world, such as real-time mood detection, advanced COVID screening, and heart rate variability analysis. Yet packaging insights from research for success

Static and Dynamic Absolute Concentration Robustness

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

Absolute Concentration Robustness (ACR) was introduced by Shinar and Feinberg (Science 327:1389-1391, 2010) as robustness of equilibrium species concentration in a mass action dynamical system. Their aim was to devise a mathematical condition that will ensure robustness in the function of the biological system being modeled. The robustness of function rests on what we refer to as empirical robustness — the

Ji Won Oh, From Grave to Cradle: Human Somatic Mosaicism and Unsolved Questions

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

사람이 어떻게 만들어지고 각 기관이 어떻게 발달하는지에 대한 질문은 아주 오래전부터 있었습니다. 체외수정(IVF)의 고유의 장점으로 인해 과학자들이 수정란을 외부에서 관찰할 수 있게 되었습니다. 하지만, 1979년도에 제정된 14일 규정(the 14-day rule)으로 인해, 수정 후 최대 14일까지의 배아 만의 연구가 가능합니다. 따라서, 이 14일 규정은 발생 생물학자들이 사람 발생학 연구에 있어서 수정 후 2주 이상(신경계 발달, 기관

Jong-Eun Park, Single-cell analysis reveals recurring programs in cancer microenvironment

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

Complexity of the cellular organization of the tumor microenvironment as an ecosystem remains to be fully appreciated. Here, for a comprehensive investigation of tumor ecosystems across a wide variety of cancer types, we performed integrative transcriptome analyses of 4.4 million single cells from 978 tumor and 474 normal samples in combination with 9,510 TCGA and

Marko Ćosić, The morphological analysis of the collagen straightness in the colon mucosa away from the cancer

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Abstract: The morphological method – based on the topology and singularity theory and originally developed for the analysis of the scattering experiments – was extended to be applicable for the analysis of biological data. The usefulness of the topological viewpoint was demonstrated by quantification of the changes of collagen fiber straightness in the human colon mucosa

Marko Ćosić, Stewart’s Catastrophic Swing

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Abstract The standard approach to problem-solving in physics consists of identifying state variables of the system, setting differential equations governing the state evolution, and solving the obtained. The behavior of the system for different values of parameters can be examined only as a fourth step. On the contrary, the modern approach to studying dynamical systems

Sungwoong Cho, HyperDeepONet: learning operator with complex target function space using the limited resources via hypernetwork

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Fast and accurate predictions for complex physical dynamics are a big challenge across various applications. Real-time prediction on resource-constrained hardware is even more crucial in the real-world problems. The deep operator network (DeepONet) has recently been proposed as a framework for learning nonlinear mappings between function spaces. However, the DeepONet requires many parameters and has

Understanding Trade-offs in Biological Information Processing

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

High accuracy of major biological processes relies on the ability of the participating enzymatic molecules to preferentially select the correct substrate from a pool of chemically similar substrates by activating the so-called proofreading mechanisms. While the importance of such mechanisms is widely accepted, it is still unclear how evolution has optimized biological systems with respect

Uncovering the mechanisms of pattern formation and emergent collective behaviors in myxobacteria

KAIST E6-1 1501 Auditorium 291 Daehak-ro, Yuseong-gu, Daejeon, Korea, Republic of

Collective cell movement is critical to the emergent properties of many multicellular systems including microbial self-organization in biofilms, wound healing, and cancer metastasis. However, even the best-studied systems lack a complete picture of how diverse physical and chemical cues act upon individual cells to ensure coordinated multicellular behavior. Myxococcus xanthus is a model bacteria famous

IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
Copyright © IBS 2021. All rights reserved.