기초과학연구원 의생명수학그룹
Cells make individual fate decisions through linear and nonlinear regulation of gene network, generating diverse dynamics from a single reaction pathway. In this colloquium, I will present two topics of …
We will discuss about “PI-VAE: Physics-Informed Variational Auto-Encoder for stochastic differential equations”, Zhong, Weiheng, and Hadi Meidani, Computer Methods in Applied Mechanics and Engineering 403 (2023): 115664. Abstract We propose …
The circadian clock orchestrates a vast array of behavioral and physiological processes with a 24-hour cycle, enabling nearly all organisms -- from bread mold to fruit-flies to humans -- to …
We will discuss about “Detecting critical state before phase transition of complex biological systems by hidden Markov model”, Chen, Pei, et al. Bioinformatics 32.14 (2016): 2143-2150. Abstract Motivation: Identifying …
Transmission of SARS-CoV-2 relies on interactions between humans. Heterogeneity and stochasticity both in human-human interactions and in the transmission of the virus give rise to non-linear infection networks that gain …
Abstract: Circadian clocks control the timing and 24-hour periodicity of virtually all physiological rhythms including sleep, cognition, and metabolism. There are optimal times for most behaviours; e.g., the best sleep …
Abstract: The ability to reliably engineer the mammalian cell will impact a variety of applications in a disruptive way, including cell fate control and reprogramming, targeted drug delivery, and regenerative …
We will discuss about “Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors”, Vipond, Oliver, et al, Proceedings of the National Academy of Sciences 118.41 (2021): e2102166118. Abstract …
Abstract: Since before the time of Aristotle and the natural philosophers, reductionism has played a foundational role in western scientific thought. The premise of reductionism is that systems can be …
Absolute Concentration Robustness (ACR) was introduced by Shinar and Feinberg (Science 327:1389-1391, 2010) as robustness of equilibrium species concentration in a mass action dynamical system. Their aim was to devise a mathematical …
We will discuss about "Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators”, Karapetyan, Sargis, and Nicolas E. Buchler,Physical Review E 92.6 (2015): 062712. Abstract Genetic oscillators, …
We will discuss about “Optimal control of aging in complex networks”, Sun, Eric D., Thomas CT Michaels, and L. Mahadevan, Proceedings of the National Academy of Sciences 117.34 (2020): 20404-20410. Abstract …