기초과학연구원 의생명수학그룹
We will discuss about “A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples ”, Nature communications 14.1 (2023): 7286. Abstract Pseudotime analysis with single-cell RNA-sequencing (scRNA-seq) data …
Abstract: The regulation and maintenance of an organ’s shape and structure is a major outstanding question in developmental biology. The Drosophila wing imaginal disc serves as a powerful system for …
We will discuss about "Reduced model for female endocrine dynamics: Validation and functional variations." Mathematical Biosciences 358 (2023): 108979. Abstract A normally functioning menstrual cycle requires significant crosstalk between hormones originating in …
We will discuss about “Transcriptome-wide analysis of cell cycle-dependent bursty gene expression from single-cell RNA-seq data using mechanistic model-based inference”, bioRxiv (2024) Abstract Bursty gene expression is quantified by two …
We will discuss about "Anti-Windup Protection Circuits for Biomolecular Integral Controllers", bioRxiv (2023). Abstract Robust Perfect Adaptation (RPA) is a desired property of biological systems wherein a system’s output …
Abstract: Circadian rhythms in physiology and behavior are regulated by circadian clocks, ubiquitous molecular transcriptional-translational feedback loops that cycle with a periodicity of ~24 hours. Circadian clocks serve as cellular …
Abstract: Wearable health trackers have shifted from gadgets for sports enthusiasts to valuable health sentinels over the last few years and that transformation is gathering pace. What do these devices …
We will discuss about "Phenotypic switching in gene regulatory networks", PNAS (2014). Abstract Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that …
We will discuss about "An improved rhythmicity analysis method using Gaussian Processes detects cell-density dependent circadian oscillations in stem cells", ArXiv (2023). Abstract Detecting oscillations in time series remains …
Abstract: Biological phenomena are notorious for crossing several temporal and spatial scales. While often it may be sufficient to focus on a single scale, it is not rare that we …
This presentation introduces an approach for estimating parameter distributions in dynamic systems modeled by differential equations. Traditional parameter estimation techniques often struggle with Repeated Cross-Sectional (RCS) data, characteristic of many …
Abstract: In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find discrete cell clusters as putative cell types, and then a statistical test is employed to …