Eui Min Jeong, A frequency-amplitude coordinator and its optimal energy consumption for biological oscillators

In this talk, we discuss the paper, “A frequency-amplitude coordinator and its optimal energy consumption for biological oscillators”, by Bo-Wei Qin et. al., Nature Communications, 2021. Zoom : https://us06web.zoom.us/j/99567630778?pwd=N2ZrUWtqZzJ0YURVTzlZT3JJR3FUQT09 Abstract  Biorhythm including neuron firing and protein-mRNA interaction are fundamental activities with diffusive effect. Their well-balanced spatiotemporal dynamics are beneficial for healthy sustainability. Therefore, calibrating both anomalous

Interpretable Machine Learning-Based Scoring System for Clinical Decision Making – Nan Liu

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: There has been an increased use of scoring systems in clinical settings for the purpose of assessing risks in a convenient manner that provides important evidence for decision making. Machine learning-based methods may be useful for identifying important predictors and building models; however, their 'black box' nature limits their interpretability as well as clinical

Yun Min Song – Noise robustness and metabolic load determine the principles of central dogma regulation

In this talk, we discuss the paper : "Noise robustness and metabolic load determine the principles of central dogma regulation" by Teresa W. Lo et al, Sci. Adv, https://doi.org/10.1126/sciadv.ado3095. Zoom: https://us06web.zoom.us/j/99567630778?pwd=N2ZrUWtqZzJ0YURVTzlZT3JJR3FUQT09 Abstract The processes of gene expression are inherently stochastic, even for essential genes required for growth. How does the cell maximize fitness in light

Latent space dynamics identification – Youngsoo Choi

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstravt: Latent space dynamics identification (LaSDI) is an interpretable data-driven framework that follows three distinct steps, i.e., compression, dynamics identification, and prediction. Compression allows high-dimensional data to be reduced so that they can be easily fit into an interpretable model. Dynamics identification lets you derive the interpretable model, usually some form of parameterized differential equations

Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment – Kevin SPINICCI

In this talk, we discuss the paper : "Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment" by Leech et al, nature biotechnology, https://doi.org/10.1371/journal.pcbi.1011879. Zoom: https://us06web.zoom.us/j/99567630778?pwd=N2ZrUWtqZzJ0YURVTzlZT3JJR3FUQT09 Abstract Collective alignment of cell populations is a commonly observed phenomena in biology. An important example

Cluster-based network modeling—From snapshots to complex dynamical systems – Olive R. Cawiding

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

Abstract: We propose a universal method for data-driven modeling of complex nonlinear dynamics from time-resolved snapshot data without prior knowledge. Complex nonlinear dynamics govern many fields of science and engineering. Data-driven dynamic modeling often assumes a low-dimensional subspace or manifold for the state. We liberate ourselves from this assumption by proposing cluster-based network modeling (CNM)

Mathematical models for malaria – Jennifer Flegg

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract:  The effect of malaria on the developing world is devastating. Each year there are more than 200 million cases and over 400,000 deaths, with children under the age of five the most vulnerable. Ambitious malaria elimination targets have been set by the World Health Organization for 2030. These involve the elimination of the disease

Next generation reservoir computing – Kang Min Lee

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

In this talk, we discuss the paper "Next generation reservoir computing", by Gauthier, et.al, Nat. Comm., 2021. Abstract : Reservoir computing is a best-in-class machine learning algorithm for processing information generated by dynamical systems using observed time-series data. Importantly, it requires very small training data sets, uses linear optimization, and thus requires minimal computing resources.

SVD-AE: An asymmetric autoencoder with SVD regularization for multivariate time series anomaly detection – Myna Lim

B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

In this talk, we discuss the paper "SVD-AE: An asymmetric autoencoder with SVD regularization for multivariate time series anomaly detection" by Yueyue Yao, et.al., Neural Networks, 2024.  Abstract  Anomaly detection in multivariate time series is of critical importance in many real-world applications, such as system maintenance and Internet monitoring. In this article, we propose a novel

Mathematical Modelling of Microtube Driven Invasion of Glioma – Thomas Hillen

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: Malignant gliomas are highly invasive brain tumors. Recent attention has focused on their capacity for network-driven invasion, whereby mitotic events can be followed by the migration of nuclei along long thin cellular protrusions, termed tumour microtubes (TM). Here I develop a mathematical model that describes this microtube-driven invasion of gliomas. I show that scaling

Theoretical studies on biological oscillations by using waveform data and mathematical models – Shingo Gibo

Title: Theoretical studies on biological oscillations by using waveform data and mathematical models Abstract: Temporal waveforms of biological oscillations are of various shapes. In our research, we have explored the functional implications of these waveform shapes. In particular, we theoretically showed that the period of circadian clocks is proportional to the waveform distortion from sinusoidal wave. It suggests that the circadian period can be stable against temperature changes only if the waveform becomes more distorted at higher temperatures. In this talk, I will explain my past research and discuss my future plans. Reference: Shingo Gibo, Gen Kurosawa, Non-sinusoidal Waveform in Temperature Compensated Circadian Oscillations, Biophysical Journal 116 (4) 741-751 (2019). doi: 10.1016/j.bpj.2018.12.022 Shingo Gibo, Gen Kurosawa, Theoretical study on the regulation of circadian rhythms by RNA methylation, Journal of Theoretical Biology 490, 110140 (2020). doi; 10.1016/j.jtbi.2019.110140 Shingo Gibo, Teiji Kunihiro, Tetsuo Hatsuda, Gen Kurosawa, Waveform

Circadian phase in cells and humans – Achim Kramer

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: Circadian clocks in cells and humans are heterogeneous in period and phase. This heterogeneity can be exploited not only to gain insight into the molecular basis of circadian rhythms, but also to explore plasticity and robustness. In this talk, I will report on two ongoing projects in the lab: (i) We are exploiting the

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