An overview of methods used for multi-scale modeling and analysis
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: TBA
12 events found.
A systems biology approach using multi-scale modeling to understand the immune response to tuberculosis infection and treatment
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at least six months. There are a number of complicating factors …
A topological data analysis based classifier
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofWe will discuss about "A topological data analysis based classifier", Kindelan et al., arXiv, 2022 Abstract: Topological Data Analysis is an emergent field that aims to discover the underlying dataset’s topological information. Topological Data Analysis tools have been commonly used to create filters and topological descriptors to improve Machine Learning (ML) methods. This paper proposes …
Dynamical and topological hallmarks of regulatory networks driving phenotypic plasticity and heterogeneity in cancers
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofThis talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Metastasis and therapy resistance cause over 90% of cancer-related deaths. Despite extensive ongoing efforts, no unique genetic or mutational signature has emerged for metastasis. Instead, the ability of genetically identical cells to adapt reversibly by exhibiting multiple phenotypes (phenotypic/non-genetic heterogeneity) and …
An Efficient Characterization of Complex-Balanced, Detailed-Balanced, and Weakly Reversible Systems
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofWe will discuss about "An Efficient Characterization of Complex-Balanced, Detailed-Balanced, and Weakly Reversible Systems", Craciun et al., SIAM Journal on Applied Mathematics, 2020 Abstract: Very often, models in biology, chemistry, physics, and engineering are systems of polynomial or power-law ordinary differential equations, arising from a reaction network. Such dynamical systems can be generated by many …
Scaling behaviors in physiological fluctuations: relevance to circadian regulation and insights into the development of Alzheimer’s disease
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Outputs from health biological systems display complex fluctuations that are not random but display robust and often self-similar (fractal) temporal correlations at different time scales— scaling behaviors. The scaling behaviors in the fluctuations of biological outputs such as neural activities, cardiac …
Toroidal topology of population activity in grid cells
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofWe will discuss about "Toroidal topology of population activity in grid cells", Gardner et al., Nature, 2021. Abstract: The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment. Grid cells, a key component of this system, fire in a characteristic hexagonal pattern of locations, …
The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofWe will discuss about "The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes", Katori et al., PNAS, 2022. Abstract: Human sleep phenotypes can be defined and diversified by both genetic and environmental factors. However, some sleep phenotypes are difficult to evaluate without long-term, precise sleep monitoring, for which simple …
Introduction to balanced networks
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: The idea of balance between excitation and inhibition is central in the theory of biological neural networks. I will give a brief introduction to the concept of such balance, and an overview of the mathematical ideas that can be used to study …
Plasticity and balance in neuronal networks
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will first describe how to extend the theory of balanced networks to account for synaptic plasticity. This theory can be used to show when a plastic network will maintain balance, and when it will be driven into an unbalanced state. …
Optimizing Oscillators for Specific Tasks Predicts Preferred Biochemical Implementations
B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic ofWe will discuss about "Optimizing Oscillators for Specific Tasks Predicts Preferred Biochemical Implementations", Agrahar and Rust., bioRxiv, 2022. Abstract: Oscillatory processes are used throughout cell biology to control time-varying physiology including the cell cycle, circadian rhythms, and developmental patterning. It has long been understood that free-running oscillations require feedback loops where the activity of one …
Stochastic modelling of reaction-diffusion processes
ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: I will introduce mathematical and computational methods for spatio-temporal modelling in molecular and cell biology, including all-atom and coarse-grained molecular dynamics (MD), Brownian dynamics (BD), stochastic reaction-diffusion models and macroscopic mean-field equations. Microscopic (BD, MD) models are based on the simulation …