Cells make individual fate decisions through linear and nonlinear regulation of gene network, generating diverse dynamics from a single reaction pathway. In this colloquium, I will present two topics of our recent work on signaling dynamics at cellular and patient levels. The first example is about the initial value of the model, as a mechanism …

The circadian clock orchestrates a vast array of behavioral and physiological processes with a 24-hour cycle, enabling nearly all organisms -- from bread mold to fruit-flies to humans -- to anticipate and adapt to the Earth's day. Entrainable by environmental cue, the rhythm itself is generated by a self-sustained molecular oscillator present in nearly every …

Transmission of SARS-CoV-2 relies on interactions between humans. Heterogeneity and stochasticity both in human-human interactions and in the transmission of the virus give rise to non-linear infection networks that gain complexity with time. We assessed the limits of control and the effect of pharmaceutical and non-pharmaceutical measures against COVID‐19 outbreaks with a detailed community‐specific agent-based model …

Abstract: Circadian clocks control the timing and 24-hour periodicity of virtually all physiological rhythms including sleep, cognition, and metabolism. There are optimal times for most behaviours; e.g., the best sleep is achieved during low circadian activity (night), while meals and physical exercise are best placed during high circadian activity (day) when metabolic rates, stress hormone …

Abstract: The ability to reliably engineer the mammalian cell will impact a variety of applications in a disruptive way, including cell fate control and reprogramming, targeted drug delivery, and regenerative medicine. However, our current ability to engineer mammalian genetic circuits that behave as predicted remains limited. These circuits depend on the intra and extra cellular …

Abstract: Since before the time of Aristotle and the natural philosophers, reductionism has played a foundational role in western scientific thought. The premise of reductionism is that systems can be broken down into constituent pieces and studied independently, then reassembled to understand the behavior of the system as a whole. It embodies the classical linear …