AI Pontryagin or how artificial neural networks learn to control dynamical systems

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "AI Pontryagin or how artificial neural networks learn to control dynamical systems", Böttcher, L., Antulov-Fantulin, N. & Asikis, T., Nat Commun 13, 333 (2022). Abstract: The efficient control of complex dynamical systems has many applications in the natural and applied sciences. In most real-world control problems, both control energy and cost

TENET+: a tool for reconstructing gene networks by integrating single cell expression and chromatin accessibility data

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation is

Chemical Organisation Theory

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Chemical Organisation Theory ", Dittrich, Peter, and Pietro Speroni Di Fenizio, Bulletin of mathematical biology 69.4 (2007): 1199-1231. Abstract: Complex dynamical reaction networks consisting of many components that interact and produce each other are difficult to understand, especially, when new component types may appear and present component types may vanish completely.

Accuracy and limitations of extrinsic noise models to describe gene expression in growing cells

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Accuracy and limitations of extrinsic noise models to describe gene expression in growing cells", Jia, Chen, and Ramon Grima, bioRxiv (2022). Abstract: The standard model describing the fluctuations of mRNA numbers in single cells is the telegraph model which includes synthesis and degradation of mRNA, and switching of the gene between

Learning stable and predictive structures in kinetic systems

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Learning stable and predictive structures in kinetic systems", Niklas Pfister , Stefan Bauer, and Jonas Peters. PNAS, 2019 Abstract: Learning kinetic systems from data is one of the core challenges in many fields. Identifying stable models is essential for the generalization capabilities of data-driven inference. We introduce a computationally efficient framework,

Neural Ordinary Differential Equations

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Neural Ordinary Differential Equations", Chen, Ricky TQ, et al., Advances in neural information processing systems 31 (2018). Abstract: We introduce a new family of deep neural network models. Instead of specifying a discrete sequence of hidden layers, we parameterize the derivative of the hidden state using a neural network. The output

Molecular convolutional neural networks with DNA regulatory circuits

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Molecular convolutional neural networks with DNA regulatory circuits", Pei, Hao, et al., Nature Machine Intelligence (2022): 1-11. Abstract: Complex biomolecular circuits enabled cells with intelligent behaviour to survive before neural brains evolved. Since DNA computing was first demonstrated in the mid-1990s, synthetic DNA circuits in liquid phase have been developed as

Circadian Interventions in Shift Workers

This talk will be given online (If you want to join, please send me an email to jaekkim@ibs.re.kr) Abstract Coupling Math with User-Centric Design Shift workers experience profound circadian disruption due to the nature of their work, which often has them on-the-clock at times when their internal clock is sending a strong, sleep-promoting signal. Mathematical

Inferring Regulatory Networks from Expression Data Using Tree-Based Methods

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Inferring Regulatory Networks from Expression Data Using Tree-Based Methods," Huynh-Thu et al., PLoS ONE (2010). Abstract: One of the pressing open problems of computational systems biology is the elucidation of the topology of genetic regulatory networks (GRNs) using high throughput genomic data, in particular microarray gene expression data. The Dialogue for

Cell signaling in 2D vs. 3D

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: The activation of Ras depends upon the translocation of its guanine nucleotide exchange factor, Sos, to the plasma membrane. Moreover, artificially inducing Sos to translocate to the plasma membrane is sufficient to bring about Ras activation and activation of Ras’s targets. There are many other examples of signaling proteins that must translocate to the

Hidden Markov models for monitoring circadian rhythmicity in telemetric activity data

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Hidden Markov models for monitoring circadian rhythmicity in telemetric activity data", Huang, Qi, Journal of The Royal Society Interface 15.139 (2018): 20170885. Abstract: Wearable computing devices allow collection of densely sampled real-time information on movement enabling researchers and medical experts to obtain objective and non-obtrusive records of actual activity of a

Physics-informed neural networks for PDE-constrained optimization and control

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Physics-informed neural networks for PDE-constrained optimization and control", Barry-Straume, Jostein, et al., arXiv preprint arXiv:2205.03377 (2022). Abstract: A fundamental problem of science is designing optimal control policies that manipulate a given environment into producing a desired outcome. Control PhysicsInformed Neural Networks simultaneously solve a given system state, and its respective optimal

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