Loading Events

« All Events

  • This event has passed.
:

Design frameworks for engineering efficient cell factory performance within host and industrial constraints

September 19, 2022 @ 1:30 pm - 2:00 pm KST

Speaker

Alexander Darlington
University of Warwick

This talk will be given online.

Abstract:

Synthetic biology and microbial biotechnology offer sustainable routes to the manufacture of commodity and high value chemicals from agricultural by-products instead of petrochemical feedstocks. However, engineered gene circuits and metabolic pathways both co-opt the cell’s gene expression machinery for protein/enzyme production and divert metabolic flux away from key host biosynthetic building blocks to a desired product. These interactions impair host growth and complicate the engineering of synthetic functions. To overcome these difficulties, we propose a host-aware engineering approach which accounts for these constraints during the circuit/pathway design process. Here we present a dynamic whole cell modelling framework of microbial growth, metabolism, and gene expression which captures key host-circuit/pathway interactions. By coupling our modelling framework with systems engineering approaches and multi-objective optimization tools, we identify key design trade-offs, make recommendations for optimal host resource usage, and develop feedback control strategies which improve pathway productivity and yields.

Details

Date:
September 19, 2022
Time:
1:30 pm - 2:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email
jaekkim@kaist.ac.kr
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
Copyright © IBS 2021. All rights reserved.