기초과학연구원 의생명수학그룹
We will discuss about "Phenotypic switching in gene regulatory networks", PNAS (2014). Abstract Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that …
We will discuss about "An improved rhythmicity analysis method using Gaussian Processes detects cell-density dependent circadian oscillations in stem cells", ArXiv (2023). Abstract Detecting oscillations in time series remains …
Abstract: Biological phenomena are notorious for crossing several temporal and spatial scales. While often it may be sufficient to focus on a single scale, it is not rare that we …
This presentation introduces an approach for estimating parameter distributions in dynamic systems modeled by differential equations. Traditional parameter estimation techniques often struggle with Repeated Cross-Sectional (RCS) data, characteristic of many …
Abstract: In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find discrete cell clusters as putative cell types, and then a statistical test is employed to …
We will discuss about “Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming”, Cell (2019). Abstract Understanding the molecular programs that guide differentiation during development is a …
We will discuss about “PenDA, a rank-based method for personalized differential analysis: Application to lung cancer” Plos Computational Biology (2020). Abstract The hopes of precision medicine rely on our capacity …
Abstract: The Downing lab investigates the intricate biophysical interactions between cells and their environment, elucidating their role in modulating adult cell behavior and phenotypic transitions via epigenetic regulation of gene …
We will discuss about “Data driven governing equations approximation using deep neural networks” Journal of Computational Physics (2019). Abstract We present a numerical framework for approximating unknown governing equations using …
In this talk, we discuss the paper "Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe", by Xiaojie Qiu et.al., Cell Syst. 2020. Abstract Here, we present …
In this talk, we discuss the paper, "MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data" by Siyao Liu et.al. Genome Biology, 2024. Abstract Single-cell …
In this talk, we will discuss the paper, "A modified shuffled frog leaping algorithm with inertia weight", by Zhuanzhe Zhao et.al. , Scientific Reports, 2024. Abstract The shuffled frog leaping …