기초과학연구원 의생명수학그룹
Abstract: Cell-to-cell variability in gene expression exists even in a homogeneous population of cells. Dissecting such cellular heterogeneity within a biological system is a prerequisite for understanding how a biological …
Program table: Topic Talk+Q&A Presenter Title Model reduction 9:00-9:10 Hyeong Jun Jang Accurate and precise estimation in enzyme inihibition 9:10-9:20 Seolah Shin Beyond Homogeneity: Assessing the Validity of the Michaelis–Menten …
Abstract: Through the past decades, electrophysiological experiments have revealed that extracellular electrical potential of brain show diverse rhythmic activity. Called ‘Local Field Potential(LFP)’, those rhythmic activities are thought to reflect …
We will discuss about “Anticipating the occurrence and type of critical transitions”, Science Advances 9.1 (2023): eabq4558. Abstract Critical transition can occur in many real-world systems. The ability to …
We will discuss about “A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples ”, Nature communications 14.1 (2023): 7286. Abstract Pseudotime analysis with single-cell RNA-sequencing (scRNA-seq) data …
Abstract: The regulation and maintenance of an organ’s shape and structure is a major outstanding question in developmental biology. The Drosophila wing imaginal disc serves as a powerful system for …
We will discuss about "Reduced model for female endocrine dynamics: Validation and functional variations." Mathematical Biosciences 358 (2023): 108979. Abstract A normally functioning menstrual cycle requires significant crosstalk between hormones originating in …
We will discuss about “Transcriptome-wide analysis of cell cycle-dependent bursty gene expression from single-cell RNA-seq data using mechanistic model-based inference”, bioRxiv (2024) Abstract Bursty gene expression is quantified by two …
We will discuss about "Anti-Windup Protection Circuits for Biomolecular Integral Controllers", bioRxiv (2023). Abstract Robust Perfect Adaptation (RPA) is a desired property of biological systems wherein a system’s output …
Abstract: Circadian rhythms in physiology and behavior are regulated by circadian clocks, ubiquitous molecular transcriptional-translational feedback loops that cycle with a periodicity of ~24 hours. Circadian clocks serve as cellular …
Abstract: Wearable health trackers have shifted from gadgets for sports enthusiasts to valuable health sentinels over the last few years and that transformation is gathering pace. What do these devices …
We will discuss about "Phenotypic switching in gene regulatory networks", PNAS (2014). Abstract Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that …