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  • scPPDM: A Diffusion Model for Single-Cell Drug-Response Prediction – Aqsa Awan

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "scPPDM: A Diffusion Model for Single-Cell Drug-Response Prediction" by Z. Liang et al., arxiv, 2025. Abstract This paper introduces the Single-Cell Perturbation Prediction Diffusion Model (scPPDM), the first diffusion-based framework for single-cell drug-response prediction from scRNA-seq data. scPPDM couples two condition channels, pre-perturbation state and drug with dose, …

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  • Leveraging Large-Scale Perturbome Data for Complex Disease Target Discovery- Sang-Min Park

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    Complex diseases, such as cancer, sarcopenia, and immune disorders, arise from abnormalities in multiple genes and pathways, posing significant challenges to conventional single-target drug discovery strategies. To address this, we developed a perturbome-based analytical framework that integrates transcriptomic signatures, network pharmacology, and machine learning to identify effective therapeutic candidates. Central to this approach is the …

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