기초과학연구원 의생명수학그룹
In this talk, we discuss the paper "Temporal tissue dynamics from a spatial snapshot" by Jonathan Somer et al., Nature, 2026. Abstract Physiological and pathological processes such as inflammation and cancer emerge from interactions between cells over time1. However, methods to follow cell populations over time within the native context of a human tissue are …
Biochemical reaction networks and gene regulatory networks in cells are prototypical examples of complex systems, characterized by highly nonlinear and stochastic, multilevel dynamical interactions. Gaining a deep understanding of the stochastic dynamics and thermodynamic principles governing biochemical reaction networks not only helps elucidate the intrinsic mechanisms underlying cell fate decisions and the onset and progression …
Stochastic modeling and analysis can help answer pressing medical questions. In this talk, I will attempt to justify this claim by describing recent work on two problems in medicine. The first problem concerns ovarian tissue cryopreservation, which is a proven tool to preserve ovarian follicles prior to gonadotoxic treatments. Can this procedure be applied to …
Data-driven modeling is essential for deciphering complex biological systems, yet its utility is often constrained by two fundamental hurdles: the inability to guarantee parameter identifiability and the high computational cost of learning nonlinear dynamics. This talk introduces a unified computational framework designed to overcome these challenges, bridging theoretical rigor with scalable machine learning. The first …
Oscillatory dynamics are a found everywhere in living systems, underlying processes such as metabolic regulation, cell division, and embryonic development. Identifying the mechanisms that generate these rhythms is challenging due to nonlinear interactions, multiple time scales, and limited access to all relevant variables. Data-driven approaches offer a promising route to infer dynamical models directly from …
Diffusive transport is one of the most fundamental mechanisms by which information, mass, and chemical signals propagate in physical and biological systems. In many settings—ranging from cellular signaling to chemical sensing—communication is mediated by particles undergoing random motion and interacting with small, spatially localized targets. This talk explores the mathematical structures underlying diffusive signaling, emphasizing …