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Candan Celik, The effect of microRNA on protein variability and gene expression fidelity

March 24, 2023 @ 2:00 pm - 4:00 pm KST

B378 Seminar room, IBS, 55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
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Speaker

Candan Celik
Biomedical Mathematics Group, IBS

We will discuss about “The effect of microRNA on protein variability and gene expression fidelity”, Hilfinger, Andreas, and Raymond Fan., Biophysical journal 122.3 (2023): 537a.

Abstract

Small regulatory RNA molecules such as microRNA modulate gene expression through inhibiting the translation of messenger RNA (mRNA). Such post-transcriptional regulation has been recently hypothesized to reduce the stochastic variability of gene expression around average levels. Here we quantify noise in stochastic gene expression models with and without such regulation. Our results suggest that silencing mRNA post-transcriptionally will always increase rather than decrease gene expression noise when the silencing of mRNA also increases its degradation as is expected for microRNA interactions with mRNA. In that regime we also find that silencing mRNA generally reduces the fidelity of signal transmission from deterministically varying upstream factors to protein levels. These findings suggest that microRNA binding to mRNA does not generically confer precision to protein expression

Details

Date:
March 24, 2023
Time:
2:00 pm - 4:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email
jaekkim@kaist.ac.kr

Venue

B378 Seminar room, IBS
55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
+ Google Map
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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