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TENET+: a tool for reconstructing gene networks by integrating single cell expression and chromatin accessibility data

July 5 @ 4:00 pm - 5:00 pm KST

B378 Seminar room, IBS, 55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of


Junil Kim
Soongsil University

Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation is still challenging. Here, we suggest an integrative strategy called TENET+ by combining single cell transcriptome and chromatin accessibility data. By applying TENET+ to a paired scRNAseq and scATACseq dataset of human peripheral blood mononuclear cells, we found critical regulators and their epigenetic regulations for the differentiations of CD4 T cells, CD8 T cells, B cells and monocytes. Interestingly, TENET+ predicted LRRFIP1 and ZBTB16 as top regulators of CD4 and CD8 T cells which were not predicted in a motif-based tool SCENIC. In sum, TENET+ is a tool predicting epigenetic gene regulatory programs in unbiased way, suggesting that novel epigenetic regulations can be identified by TENET+.


July 5
4:00 pm - 5:00 pm KST
Event Category:


B378 Seminar room, IBS
55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of


Jae Kyoung Kim
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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