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Phiclust: a clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations

February 11 @ 1:00 pm - 2:00 pm KST

B378 Seminar room, IBS, 55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
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Speaker

Hyun Kim
ibs biomedical mathematics group
https://sites.google.com/view/hyun-kim/

We will discuss about “Phiclust: a clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations”, Mircea et al., 2022, Genome Biology

The ability to discover new cell phenotypes by unsupervised clustering of single-cell transcriptomes has revolutionized biology. Currently, there is no principled way to decide whether a cluster of cells contains meaningful subpopulations that should be further resolved. Here, we present phiclust (ϕ_clust), a clusterability measure derived from random matrix theory that can be used to identify cell clusters with non-random substructure, testably leading to the discovery of previously overlooked phenotypes.

Details

Date:
February 11
Time:
1:00 pm - 2:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email:
jaekkim@kaist.ac.kr

Venue

B378 Seminar room, IBS
55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
+ Google Map
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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