In this talk, we discuss the paper "Feature selection and dimension reduction for single-cell RNA-Seq based on a multinomial model" by F. W. Townes et.al., Genome Biology, 2019. Abstract  Single-cell RNA-Seq (scRNA-Seq) profiles gene expression of individual cells. Recent scRNA-Seq datasets have incorporated unique molecular identifiers (UMIs). Using negative controls, we show UMI counts follow …

In this talk, we discuss the paper "CARE as a wearable derived feature linking circadian amplitude to human cognitive functions" by Shuya Cui et.al., npj Digital Medicine, 2023. Abstract Circadian rhythms are crucial for regulating physiological and behavioral processes. Pineal hormone melatonin is often used to measure circadian amplitude but its collection is costly and …

In this talk, we discuss the paper "Plausible, robust biological oscillations through allelic buffering" by F-S. Hsieh et.al, Cell Systems, 2024. at the Journal Club.  Abstract Biological oscillators can specify time- and dose-dependent functions via dedicated control of their oscillatory dynamics. However, how biological oscillators, which recurrently activate noisy biochemical processes, achieve robust oscillations remains …

In this talk, we discuss the paper "Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality" by H. Yuan et.al, npj digital medicine, 2024, at the Journal Club. Abstract  Sleep is essential to life. Accurate measurement and classification of sleep/wake and sleep stages is important in clinical studies for …