We will discuss about "Hard limits and performance tradeoffs in a class of antithetic integral feedback networks." Cell systems 9.1 (2019): 49-63. Abstract Feedback regulation is pervasive in biology at both the organismal and cellular level. In this article, we explore the properties of a particular biomolecular feedback mechanism called antithetic integral feedback, which can …

We will discuss about “Time delays modulate the stability of complex ecosystems” Nature Ecology & Evolution 7.10 (2023): 1610-1619. Abstract What drives the stability, or instability, of complex ecosystems? This question sits at the heart of community ecology and has motivated a large body of theoretical work exploring how community properties shape ecosystem dynamics. However, the …

We will discuss about “Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination” bioRxiv (2023): 2023-10. Abstract Entrainment to an external stimulus enables a synchronized oscillatory response across a population of cells, increasing coherent responses by reducing cell-to-cell heterogeneity. It is unclear whether the property of entrainability extends to systems where responses are …

We will discuss about “MultiVI: deep generative model for the integration of multimodal data” Nature Methods 20.8 (2023): 1222-1231. Abstract Jointly profiling the transcriptome, chromatin accessibility and other molecular properties of single cells offers a powerful way to study cellular diversity. Here we present MultiVI, a probabilistic model to analyze such multiomic data and leverage …