기초과학연구원 의생명수학그룹
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We will discuss about "A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light", Kumpost et al., bioRxiv (2021) The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock, … |
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We will discuss about "Highly accurate fluorogenic DNA sequencing with information theory–based error correction", Chen et al., Nature Biotechnology (2017) Eliminating errors in next-generation DNA sequencing has proved challenging. Here we present error-correction code (ECC) sequencing, a method to greatly improve sequencing accuracy by combining fluorogenic sequencing-by-synthesis (SBS) with an information theory–based error-correction algorithm. ECC … |
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This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Life science has been a prosperous subject for a long time, and is still developing with high speed now. One of its major aims is to study the mechanisms of various biological processes on the basis of biological big-data. Many statistics-based … |
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We will discuss about "Synthetic multistability in mammalian cells", Zhu et al., bioRxiv (2021) In multicellular organisms, gene regulatory circuits generate thousands of molecularly distinct, mitotically heritable states, through the property of multistability. Designing synthetic multistable circuits would provide insight into natural cell fate control circuit architectures and allow engineering of multicellular programs that require … |
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This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Facebook live streaming: https://www.facebook.com/10226475900150025/videos/10226475902790091 Age brings the benefit of experience and looking back at my job as a professor, there are a couple of things that fall into the category “I wish someone had told me that earlier”. In this seminar, I … |
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We will discuss about "A Simple and Flexible Computational Framework for Inferring Sources of Heterogeneity from Single-Cell Dynamics", Dharmarajan et al., Cell Systems (2019) Single-cell time-lapse data provide the means for disentangling sources of cell-to-cell and intra-cellular variability, a key step for understanding heterogeneity in cell populations. However, single-cell analysis with dynamic models is a … |
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In this talk, the speaker will present introductory materials about Bayesian Machine Learning. Abstract Gaussian process(GP) is a stochastic process such that the joint distribution of an arbitrary finite subset of the random variables is a multivariate normal. It plays a fundamental role in Bayesian machine learning as it can be interpreted as a prior … |
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Oscillatory signals are ubiquitously observed in many different intracellular systems such as immune systems and DNA repair processes. While we know how oscillatory signals are created, we do not fully understand what a critical role they play to regulate signal pathway systems in cells. Recently by using a stochastic nucleosome system, we found that a … |
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