기초과학연구원 의생명수학그룹
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We will discuss about "Pairing of segmentation clock genes drives robust pattern formation", Zinani et al., Nature (2021) Gene expression is an inherently stochastic process; however, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans, pairs of co-expressed genes often reside in the same chromosomal neighbourhood, … |
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We will discuss about "Maximum Entropy Framework for Predictive Inference of Cell Population Heterogeneity and Responses in Signaling Networks", Dixit et al., Cell Systems (2020) Predictive models of signaling networks are essential for understanding cell population heterogeneity and designing rational interventions in disease. However, using computational models to predict heterogeneity of signaling dynamics is often … |
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In this presentation, we are going to discuss the paper, "Unified rational protein engineering with sequence-based deep representation learning" Abstract Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich … |
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Registration is required to attend this talk (link: https://www.ibric.org/seminar/#), and it will be presented in Korean. Abstract: 생체 시계 (Circadian clock)를 구성하는 핵심 단백질인 PERIOD (PER)의 양은 12시간 동안 증가했다가 12시간 동안 감소하며 24시간 주기로 변화한다. 이 24시간 주기의 PER 리듬이 우리 몸의 시계 역할을 하여 수면 시간 등 다양한 행동 및 생리 작용의 시간을 … |
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This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Millions of individuals track their steps, heart rate, and other physiological signals through wearables. This data scale is unprecedented; I will describe several of our apps and ongoing studies, each of which collects wearable and mobile data from thousands of users, … |
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We will discuss about "A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light", Kumpost et al., bioRxiv (2021) The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock, … |
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