기초과학연구원 의생명수학그룹
We will discuss about “The Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction ”, Qi et al., iScience, 2020 Abstract: Although a rising concentration of cytosolic Ca2+ has long been recognized as an essential signal for apoptosis, the dynamical mechanisms by which Ca2+ regulates apoptosis are not clear yet. To address this, we constructed …
We will discuss about “A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells”, Unosson et al., bioRxiv, 2021 We propose a stochastic distributed delay model together with a Markov random field prior and a measurement model for bioluminescence-reporting to analyse spatiotemporal gene expression in intact …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors. …
We will discuss about “Balanced truncation for model reduction of biological oscillators”, Padoan et al., Biological Cybernetics, 2021 Model reduction is a central problem in mathematical biology. Reduced order models enable modeling of a biological system at different levels of complexity and the quantitative analysis of its properties, like sensitivity to parameter variations and resilience …
Sleep Tree: A workshop on an interdisciplinary approach to sleep disorders. This workshop is an interdisciplinary workshop across Mathematics, Medicine, Psychology, and Psychiatry to investigate sleep disorders. Researchers from groups led by Prof. Jae Kyoung Kim (KAIST/IBS), Sooyeon Suh (Sungshin Women's Univ.), Eun Yeon Joo (Sungkyunkwan Univ./Samsung Medical Center), and Su Jung Choi (Sungkyunkwan Univ./ …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration …
We will discuss about “Filtering and inference for stochastic oscillators with distributed delays”, Calderazzo et al., Bioinformatics, 2018 at the Journal Club Motivation The time evolution of molecular species involved in biochemical reaction networks often arises from complex stochastic processes involving many species and reaction events. Inference for such systems is profoundly challenged by the …
Abstract TBA
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Chronotherapeutics- that is administering drugs following the patient's biological rhythms over the 24 h span- may largely impact on both drug toxicities and efficacy in various pathologies including cancer . However, recent findings highlight the critical need of personalizing circadian delivery …
(1) GCN and its Application. We introduce the GCN by reviewing the monumental paper " Semi-Supervised Classification with the Graph Convolutional Networks", ICLR 2018 by Kipf and Welling. We are going to much detail the algorithm of message aggregation and passings and learning processes. Code ; https://github.com/tkipf/gcn (2) Graph Attention networks(GAT) and its Applications. Bengio …
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: From fertilization to birth, successful mammalian reproduction relies on interactions of elastic structures with a fluid environment. Sperm flagella must move through cervical mucus to the uterus and into the oviduct, where fertilization occurs. In fact, some sperm may adhere to …
We will discuss about “Detecting and quantifying causal associations in large nonlinear time series datasets”, Runge et al., Science Advances, 2019 Identifying causal relationships and quantifying their strength from observational time series data are key problems in disciplines dealing with complex dynamical systems such as the Earth system or the human body. Data-driven causal inference …