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Yun Min Song, On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism

KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

We will discuss about "On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism", bioRxiv (2021). The conditions for the validity of the standard quasi-steady-state approximation in the Michaelis--Menten mechanism in a closed reaction vessel have been well studied, but much less so the conditions for the validity of this approximation for the system with …

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Hyukpyo Hong, Frequency Spectra and the Color of Cellular Noise

KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

We will discuss about "Frequency Spectra and the Color of Cellular Noise",  bioRxiv (2020). The invention of the Fourier integral in the 19th century laid the foundation for modern spectral analysis methods. By decomposing a (time) signal into its essential frequency components, these methods uncovered deep insights into the signal and its generating process, precipitating …

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Eui Min Jeong, Pairing of segmentation clock genes drives robust pattern formation

Tea Room, IBS Daejeon, Daejeon, Korea, Republic of

We will discuss about "Pairing of segmentation clock genes drives robust pattern formation", Zinani et al., Nature (2021) Gene expression is an inherently stochastic process; however, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans, pairs of co-expressed genes often reside in the same chromosomal neighbourhood, …

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Dae Wook Kim, Maximum Entropy Framework for Predictive Inference of Cell Population Heterogeneity and Responses in Signaling Networks

Tea Room, IBS Daejeon, Daejeon, Korea, Republic of

We will discuss about "Maximum Entropy Framework for Predictive Inference of Cell Population Heterogeneity and Responses in Signaling Networks", Dixit et al., Cell Systems (2020) Predictive models of signaling networks are essential for understanding cell population heterogeneity and designing rational interventions in disease. However, using computational models to predict heterogeneity of signaling dynamics is often …

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Seokjoo Chae, Unified rational protein engineering with sequence-based deep representation learning

Tea Room, IBS Daejeon, Daejeon, Korea, Republic of

In this presentation, we are going to discuss the paper, "Unified rational protein engineering with sequence-based deep representation learning" Abstract Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich …

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Dae Wook Kim, Revealing causes of disrupted wake-sleep cycles using mathematical model (BRIC Webinar)

Registration is required to attend this talk (link: https://www.ibric.org/seminar/#), and it will be presented in Korean. Abstract: 생체 시계 (Circadian clock)를 구성하는 핵심 단백질인 PERIOD (PER)의 양은 12시간 동안 증가했다가 12시간 동안 감소하며 24시간 주기로 변화한다. 이 24시간 주기의 PER 리듬이 우리 몸의 시계 역할을 하여 수면 시간 등 다양한 행동 및 생리 작용의 시간을 …

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Daniel Forger, The mathematics of the wearables with applications to circadian rhythms and sleep

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Millions of individuals track their steps, heart rate, and other physiological signals through wearables. This data scale is unprecedented; I will describe several of our apps and ongoing studies, each of which collects wearable and mobile data from thousands of users, …

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Yun Min Song, A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light

B305 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light", Kumpost et al., bioRxiv (2021) The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock, …

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Highly accurate fluorogenic DNA sequencing with information theory–based error correction

B305 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about "Highly accurate fluorogenic DNA sequencing with information theory–based error correction", Chen et al., Nature Biotechnology (2017) Eliminating errors in next-generation DNA sequencing has proved challenging. Here we present error-correction code (ECC) sequencing, a method to greatly improve sequencing accuracy by combining fluorogenic sequencing-by-synthesis (SBS) with an information theory–based error-correction algorithm. ECC …

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Livestream

Dynamics-based data science in biology

ZOOM ID: 709 120 4849 (ibsbimag) (pw: 1234)

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Life science has been a prosperous subject for a long time, and is still developing with high speed now. One of its major aims is to study the mechanisms of various biological processes on the basis of biological big-data. Many statistics-based …

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IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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