• Jooyoung Hahn – Topological Data Analysis with two applications: Tumor Microenvironment and 2D Chromatography with High-Resolution Mass Spectrometry

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    Abstract  Topological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional, complex datasets. In this talk, we present two applications of TDA in analyzing patterns, one in the tumor microenvironment (TME) and the other in high-resolution chemical profiling. In the first case, we develop a TDA-based framework to quantify malignant-immune cell interactions

  • Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan – Yun Min Song

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan" by J. Shim et.al., npj digital medicine, 2024. Abstract Recognizing the pivotal role of circadian rhythm in the human aging process and its scalability through wearables, we introduce CosinorAge, a digital biomarker of aging

  • Statistical method scDEED for detecting dubious 2D single-cell embeddings and optimizing t-SNE and UMAP hyperparameters – Kevin Spinicci

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Statistical method scDEED for detecting dubious 2D single-cell embeddings and optimizing t-SNE and UMAP hyperparameters" by L. Xia et.al. Nature Communications, 2024. Abstract Two-dimensional (2D) embedding methods are crucial for single-cell data visualization. Popular methods such as t-distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation and projection

  • Binning as a Pretext Task: Improving Self-Supervised Learning in Tabular Domains – Jinwoo Hyun

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Binning as a Pretext Task: Improving Self-Supervised Learning in Tabular Domains" by K. Lee. Abstract The ability of deep networks to learn superior representations hinges on leveraging the proper inductive biases, considering the inherent properties of datasets. In tabular domains, it is critical to effectively handle heterogeneous features

  • Weak form SciML in the Life Sciences: The Weak Form is Stronger than you Think – David Bortz

    ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

    Abstract The creation and inference of mathematical models is central to modern scientific discovery in the life sciences. As more realism is demanded of models, however, the conventional framework of biology-guided model proposal, discretization, parameter estimation, and model refinement becomes unwieldy, expensive, and computationally daunting. Recent advances in Weak form-based Scientific Machine Learning (WSciML) allow

  • Physics-constrained neural ordinary differential equation models to discover and predict microbial community dynamics – Kang Min Lee

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Physics-constrained neural ordinary differential equation models to discover and predict microbial community dynamics" by J. Thompson et al., bioarxiv, 2025. Abstract Microbial communities play essential roles in shaping ecosystem functions and predictive modeling frameworks are crucial for understanding, controlling, and harnessing their properties. Competition and cross-feeding of metabolites

  • Decomposing causality into its synergistic, unique, and redundant components – Olive Cawiding

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Decomposing causality into its synergistic, unique, and redundant components" by Álvaro Martínez-Sánchez et al., Nature Communications, 2024. Abstract Causality lies at the heart of scientific inquiry, serving as the fundamental basis for understanding interactions among variables in physical systems. Despite its central role, current methods for causal inference

  • SCassist: An AI Based Workflow Assistant for Single-Cell Analysis – Aqsa Awan

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "SCassist: An AI Based Workflow Assistant for Single-Cell Analysis " by Vijayaraj Nagarajan et al., bioarxiv, 2025.  Abstract Single-cell RNA sequencing (scRNA-seq) data analysis often involves complex iterative workflow, requiring significant expertise and time. To navigate this complexity, we have developed SCassist, an R package that leverages the power

  • Sleep as part of the 24-hour day: Methods and Applications in Oncology – Joshua Wiley

    ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

    Abstract Sleep is commonly analysed as an independent factor. However, because of the 24-hour constraints on a day, changes in sleep will co-occur with changes in remaining time use. This talk introduces compositional data analysis (CoDA) for sleep research. CoDA is illustrated using 24-hour sleep and activity data from accelerometry, first cross-sectionally showing associations between

  • Tackling inter-subject variability in smartwatch data using factorization models – Myna Lim

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "Tackling inter-subject variability in smartwatch data using factorization models" by Arman Naseri et. al, Scientific Reports, 2025. Abstract Smartwatches enable longitudinal and continuous data acquisition. This has the potential to remotely monitor (changes) of the health of users. However, differences among subjects (inter-subject variability) limit a model to

  • Excess Mortality, Two Lenses : Healthcare Access and Cross-National Time Trends – Daeil Jang

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    Abstract Background : Excess mortality captures both the direct and indirect impacts of the pandemic. We examine (1) within-country heterogeneity by healthcare access over distinct viral waves in Korea, and (2) cross-country associations between excess mortality and preparedness (Global Health Security, GHS), stratified by IMF development stage. Methods : Study 1 assembled a region-level panel

  • Topological Data Analysis for Multiscale Biology – Heather Harrington

    ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

    Abstract Many processes in the life sciences are inherently multi-scale and dynamic. Spatial structures and patterns vary across levels of organisation, from molecular to multi-cellular to multi-organism. With more sophisticated mechanistic models and data available, quantitative tools are needed to study their evolution in space and time. Topological data analysis (TDA) provides a multi-scale summary

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