Seokjoo Chae, Improving gene regulatory network inference and assessment: The importance of using network structure

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about “Improving gene regulatory network inference and assessment: The importance of using network structure”, Escorcia-Rodríguez, Juan M., et al., bioRxiv (2023): 2023-01. Abstract Gene regulatory networks are graph models representing cellular transcription events. Networks are far from complete due to time and resource consumption for experimental validation and curation of the interactions. Previous

Hans P.A. Van Dongen, Modeling the temporal dynamics of neurobehavioral performance impairment due to sleep loss and circadian misalignment

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: The well-known two-process model of sleep regulation makes accurate predictions of sleep timing and duration, as well as neurobehavioral performance, for a variety of acute sleep deprivation and nap sleep scenarios, but it fails to predict the effects of chronic sleep restriction on neurobehavioral performance. The two-process model belongs to a broader class of

Understanding Trade-offs in Biological Information Processing

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

High accuracy of major biological processes relies on the ability of the participating enzymatic molecules to preferentially select the correct substrate from a pool of chemically similar substrates by activating the so-called proofreading mechanisms. While the importance of such mechanisms is widely accepted, it is still unclear how evolution has optimized biological systems with respect

Uncovering the mechanisms of pattern formation and emergent collective behaviors in myxobacteria

KAIST E6-1 1501 Auditorium 291 Daehak-ro, Yuseong-gu, Daejeon, Korea, Republic of

Collective cell movement is critical to the emergent properties of many multicellular systems including microbial self-organization in biofilms, wound healing, and cancer metastasis. However, even the best-studied systems lack a complete picture of how diverse physical and chemical cues act upon individual cells to ensure coordinated multicellular behavior. Myxococcus xanthus is a model bacteria famous

Kyongwon Kim, On sufficient graphical models

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We introduce a sufficient graphical model by applying the recently developed nonlinear sufficient dimension reduction techniques to the evaluation of conditional independence. The graphical model is nonparametric in nature, as it does not make distributional assumptions such as the Gaussian or copula Gaussian assumptions. However, unlike a fully nonparametric graphical model, which relies on the

Hyukpyo Hong, Inference and uncertainty quantification of stochastic gene expression via synthetic models

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about “Inference and uncertainty quantification of stochastic gene expression via synthetic models”, Öcal et al., J. R. Soc. Interface. Abstract Estimating uncertainty in model predictions is a central task in quantitativebiology. Biological models at the single-cell level are intrinsically stochastic and nonlinear, creating formidable challenges for their statistical estimation which inevitably has

Dongju Lim, A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer’s disease

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about “A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer’s disease”, Alexandersen, Christoffer G., et al., Journal of the Royal Society Interface 20.198 (2023): 20220607. Abstract Alzheimer’s disease is the most common cause of dementia and is linked to the spreading of pathological amyloid-β and tau proteins throughout the brain. Recent studies

Thomas Philipp, Stochastic gene expression in lineage trees

ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium) (pw: 1234)

Abstract: Stochasticity in gene expression is an important source of cell-to-cell variability (or noise) in clonal cell populations. So far, this phenomenon has been studied using the Gillespie Algorithm, or the Chemical Master Equation, which implicitly assumes that cells are independent and do neither grow nor divide. This talk will discuss recent developments in modelling

Nonparametric predictive model for sparse and irregular longitudinal data

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We propose a kernel-based estimator to predict the mean response trajectory for sparse and irregularly measured longitudinal data. The kernel estimator is constructed by imposing weights based on the subject-wise similarity on L2 metric space between predictor trajectories, where we assume that an analogous fashion in predictor trajectories over time would result in a similar

Hyeontae Jo,Parameter Estimation of Power Electronic Converters With Physics-Informed Machine Learning

B378 Seminar room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Korea, Republic of

We will discuss about “Parameter Estimation of Power Electronic Converters With Physics-Informed Machine Learning”, Zhao, Shuai, et al., IEEE Transactions on Power Electronics 37.10 (2022): 11567-11578. Abstract Physics-informed machine learning (PIML) has been emerging as a promising tool for applications with domain knowledge and physical models. To uncover its potentials in power electronics, this article

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