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  • Dae Wook Kim, Neural network aided approximation and parameter inference of stochastic models of gene expression

    KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

    We will discuss about "Neural network aided approximation and parameter inference of stochastic models of gene expression", Jian et al., bioRxiv (2020). Non-Markov models of stochastic biochemical kinetics often incorporate explicit time delays to effectively model large numbers of intermediate biochemical processes. Analysis and simulation of these models, as well as the inference of their …

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  • Seokjoo Chae, Ligand-receptor promiscuity enables cellular addressing

    KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

    We will discuss about "Ligand-receptor promiscuity enables cellular addressing", Su et al., bioRxiv (2021) In multicellular organisms, secreted ligands selectively activate, or “address,” specific target cell populations to control cell fate decision-making and other processes. Key cell-cell communication pathways use multiple promiscuously interacting ligands and receptors, provoking the question of how addressing specificity can emerge …

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  • Seokjoo Chae, Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression

    KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

    We will discuss about "Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression", Benzinger et al., bioRxiv (2021) Cells live in constantly changing environments and employ dynamic signaling pathways to transduce information about the signals they encounter. However, the mechanisms by which dynamic signals are decoded into appropriate gene expression patterns remain poorly …

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  • Yun Min Song, On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism

    KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

    We will discuss about "On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism", bioRxiv (2021). The conditions for the validity of the standard quasi-steady-state approximation in the Michaelis--Menten mechanism in a closed reaction vessel have been well studied, but much less so the conditions for the validity of this approximation for the system with …

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  • Hyukpyo Hong, Frequency Spectra and the Color of Cellular Noise

    KAIST E2-1 room 3221 E2-1 building, Daejeon, Daejeon, Korea, Republic of

    We will discuss about "Frequency Spectra and the Color of Cellular Noise",  bioRxiv (2020). The invention of the Fourier integral in the 19th century laid the foundation for modern spectral analysis methods. By decomposing a (time) signal into its essential frequency components, these methods uncovered deep insights into the signal and its generating process, precipitating …

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  • Eui Min Jeong, Pairing of segmentation clock genes drives robust pattern formation

    Tea Room, IBS Daejeon, Daejeon, Korea, Republic of

    We will discuss about "Pairing of segmentation clock genes drives robust pattern formation", Zinani et al., Nature (2021) Gene expression is an inherently stochastic process; however, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans, pairs of co-expressed genes often reside in the same chromosomal neighbourhood, …

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