Journal Club

We will discuss about “A trade-off in controlling upstream and downstream noise in signaling networks”, bioRxiv (2023): 2023-08.   Abstract Signal transduction, underpinning the function of a variety of biological systems, is inevitably affected by fluctuations. It remains intriguing how the timescale of a signaling network relates to its capability of noise control, specifically, whether long …

We will discuss about “Anticipating the occurrence and type of critical transitions”, Science Advances 9.1 (2023): eabq4558.   Abstract Critical transition can occur in many real-world systems. The ability to forecast the occurrence of transition is of major interest in a range of contexts. Various early warning signals (EWSs) have been developed to anticipate the …

We will discuss about “A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples ”, Nature communications 14.1 (2023): 7286.   Abstract Pseudotime analysis with single-cell RNA-sequencing (scRNA-seq) data has been widely used to study dynamic gene regulatory programs along continuous biological processes. While many methods have been developed to infer the pseudotemporal trajectories …