Journal Club

We will discuss about "Approximating Solutions of the Chemical Master Equation using Neural Networks", Sukys et al., bioRxiv, 2022 Abstract: The Chemical Master Equation (CME) provides an accurate description of stochastic biochemical reaction networks in well-mixed conditions, but it cannot be solved analytically for most systems of practical interest. While Monte Carlo methods provide a …

We will discuss about "Identifying the critical states of complex diseases by the dynamic change of multivariate distribution", Peng, Hao, et al., Briefings in Bioinformatics, 2022. Abstract: The dynamics of complex diseases are not always smooth; they are occasionally abrupt, i.e. there is a critical state transition or tipping point at which the disease undergoes …

We will discuss about "Understanding How Dimension Reduction Tools Work: An Empirical Approach to Deciphering t-SNE, UMAP, TriMAP, and PaCMAP for Data Visualization", Wang, Yingfan, et al., J. Mach. Learn. Res., 2021. Abstract: Dimension reduction (DR) techniques such as t-SNE, UMAP, and TriMAP have demonstrated impressive visualization performance on many real world datasets. One tension …