기초과학연구원 의생명수학그룹
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Abstract: The regulation and maintenance of an organ’s shape and structure is a major outstanding question in developmental biology. The Drosophila wing imaginal disc serves as a powerful system for elucidating design principles of the shape formation in epithelial morphogenesis. |
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Brenda Lyn Gavina, Reduced model for female endocrine dynamics: Validation and functional variations
Brenda Lyn Gavina, Reduced model for female endocrine dynamics: Validation and functional variations
We will discuss about "Reduced model for female endocrine dynamics: Validation and functional variations." Mathematical Biosciences 358 (2023): 108979. Abstract A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle … |
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We will discuss about “Transcriptome-wide analysis of cell cycle-dependent bursty gene expression from single-cell RNA-seq data using mechanistic model-based inference”, bioRxiv (2024) Abstract Bursty gene expression is quantified by two intuitive parameters: the burst frequency and the burst size. While these parameters are known to be cell-cycle dependent for some genes, a transcriptome-wide picture remains … |
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We will discuss about "Anti-Windup Protection Circuits for Biomolecular Integral Controllers", bioRxiv (2023). Abstract Robust Perfect Adaptation (RPA) is a desired property of biological systems wherein a system’s output perfectly adapts to a steady state, irrespective of a broad class of perturbations. Achieving RPA typically requires the deployment of integral controllers, which continually adjust … |
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Abstract: Circadian rhythms in physiology and behavior are regulated by circadian clocks, ubiquitous molecular transcriptional-translational feedback loops that cycle with a periodicity of ~24 hours. Circadian clocks serve as cellular timekeepers regulating important cell-type specific functions. The phase of circadian rhythms and circadian clocks throughout the body are entrained to the light cycle by signals … |
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