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  • High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis – Hyeong Jun Jang

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper "High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis" by Divya Singh et al., Nat. Comm., 2025. Abstract Single-molecule measurements provide a platform for investigating the dynamical properties of enzymatic reactions. To this end, the single-molecule Michaelis-Menten equation was instrumental as it asserts that the …

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  • Heejung Shim – Modelling spatial transcriptomics: from flexible cell-type deconvolution to multi-scale spatial factor analysis

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    Abstract: Spatial transcriptomics enables the study of gene expression within its spatial context, but introduces key statistical challenges, including mixed cellular composition and complex spatial structure. In this talk, I present two complementary modelling approaches.First, I introduce FlexiDeconv, a cell-type deconvolution method based on a modified Latent Dirichlet Allocation framework. A key feature of this …

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  • Bridging known and unknown dynamics by transformer-based machine-learning inference from sparse observations – Gyuyoung Hwang

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper “Bridging known and unknown dynamics by transformer-based machine-learning inference from sparse observations” by Zheng-Meng Zhai et al., Nature Communications, 2025. Abstract: In applications, an anticipated issue is where the system of interest has never been encountered before and sparse observations can be made only once. Can the dynamics …

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  • Mathematics of diffusive signaling – Alan Lindsay

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    Diffusive transport is one of the most fundamental mechanisms by which information, mass, and chemical signals propagate in physical and biological systems. In many settings—ranging from cellular signaling to chemical sensing—communication is mediated by particles undergoing random motion and interacting with small, spatially localized targets. This talk explores the mathematical structures underlying diffusive signaling, emphasizing …

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  • Circadian rhythm profiles derived from accelerometer measures of the sleep-wake cycle in two cohort studies – Chitaranjan Mahapatra

    B232 Seminar Room, IBS 55 Expo-ro Yuseong-gu, Daejeon, Daejeon, Korea, Republic of

    In this talk, we discuss the paper “Circadian rhythm profiles derived from accelerometer measures of the sleep-wake cycle in two cohort studies” by Sam vidil et al., Nature Communications, 2025. Abstract: Accelerometers allow objective measures of dimensions (rest-activity rhythm (RAR), daytime activity, sleep, and chronotype) of the bio-behavioural manifestation of circadian rhythm (CR) using multiple …

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