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Bayesian model calibration and sensitivity analysis for oscillating biochemical experiments

July 28 @ 1:00 pm - 2:00 pm KST

B305 Seminar room, IBS, 55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
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Abstract: Most organisms exhibit various endogenous oscillating behaviors, which provides crucial information about how the internal biochemical processes are connected and regulated. Along with physical experiments, studying such periodicity of organisms often utilizes computer experiments relying on ordinary differential equations (ODE) because configuring the internal processes is difficult. Simultaneously utilizing both experiments, however, poses a significant statistical challenge due to its ill behavior in high dimension, identifiability, and numerical instability. This article devises a new Bayesian calibration strategy for oscillating biochemical models. The proposed methodology can efficiently estimate the computer experiments’ (ODE) parameters that match the physical experiments. The proposed framework is illustrated with circadian oscillations observed in a model filamentous fungus, Neurospora crassa.

Details

Date:
July 28
Time:
1:00 pm - 2:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email:
jaekkim@kaist.ac.kr

Venue

B305 Seminar room, IBS
55 Expo-ro Yuseong-gu
Daejeon, 34126 Korea, Republic of
+ Google Map
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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