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Scaling in development

November 4 @ 11:00 am - 12:00 pm KST

ZOOM ID: 709 120 4849 (ibsbimag), (pw: 1234) + Google Map
This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234)

Abstract:

 Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration and has long fascinated scientists. I will first discuss a generic theoretical framework to show how scaling gene expression pattern can emerge from non-scaling morphogen gradients. I will then demonstrate that the Drosophila gap gene system achieves scaling in a way that is entirely consistent with our theory. Remarkably, a parameter-free model based on the theory quantitatively accounts for the gap gene expression pattern in nearly all morphogen mutants. Furthermore, the regulation logic and the coding/decoding strategy of the gap gene system can be revealed. Our work provides a general theoretical framework on a large class of problems where scaling output is induced by non-scaling input, as well as a unified understanding of scaling, mutants’ behavior and regulation in the Drosophila gap gene and related systems.

Details

Date:
November 4
Time:
11:00 am - 12:00 pm KST
Event Category:

Organizer

Jae Kyoung Kim
Email:
jaekkim@kaist.ac.kr

Venue

ZOOM ID: 709 120 4849 (ibsbimag)
(pw: 1234) + Google Map
IBS 의생명수학그룹 Biomedical Mathematics Group
기초과학연구원 수리및계산과학연구단 의생명수학그룹
대전 유성구 엑스포로 55 (우) 34126
IBS Biomedical Mathematics Group (BIMAG)
Institute for Basic Science (IBS)
55 Expo-ro Yuseong-gu Daejeon 34126 South Korea
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