Collaborators

Mathematics

Krešimir Josić

Department of Mathematics, U of Houston, USA

Collaborative works
Hierarchical Bayesian models of transcriptional and translational regulation processes with delays, Bioinformatics (2021)
Long-range temporal coordination of gene expression in spatially extended synthetic microbial consortia, Nature Chem Biol (2019)
Bayesian inference of distributed time delay in transcriptional and translational regulation, Bioinformatics (2019)
The relationship between deterministic and stochastic quasi-steady-state approximation, BMC Syst Biol (2015)
Emergent genetic oscillations in a synthetic microbial consortium, Science (2015)
The Validity of Quasi-Steady-State Approximations in Discrete Stochastic Simulations, Biophy J (2014)
Molecular mechanisms that regulate the coupled period of the mammalian circadian clock, Biophy J (2014)
Curriculum-based Reinforcement Learning for Adaptive Hyperparameter Tuning in Hamiltonian Monte Carlo

John Tyson

Department of Biological Sciences, Virginia Tech, USA

Collaborative works
Time-keeping and decision-making in living cells: Part II, Interface Focus (2022)
Time-keeping and decision-making in living cells: Part I, Interface Focus (2022)
Misuse of the Michaelis-Menten rate law for protein-interaction networks and its remedy, PLoS Comput Biol (2020)
A systems-driven experimental approach reveals the complex regulatory distribution of p53 by circadian factors, PNAS (2016)


Sookkyung Lim

Mathematical Sciences, University of Cincinnati, USA

Collaborative works
Modeling reveals a key mechanism for light-dependent phase shifts of Neurospora circadian rhythms, Biophy J (2018)

Grzegorz Rempala

Division of Biostatistics and Mathematical Biosciences Institute, The Ohio State University, USA

Collaborative works
Reduction for stochastic reaction network with multi-scale conservation, SIAM Multiscale Model Simul (2017)
Beyond Michaelis-Menten: Accurate and efficient estimation of enzyme kinetic parameters, Scientific Report (2017)

Eduardo D. Sontag

Departments of Electrical and Computer Engineering and of Bioengineering, Northeastern University, USA

Collaborative works
Derivation of stationary distributions of biochemical reaction networks via structure transformation, Communications Biology (2021)
Reduction of Multiscale Stochastic Biochemical Reaction Networks using Exact Moment Derivation, PLoS Comput Biol (2017)

Victoria Booth

Department of Mathematics, U of Michigan, USA

Collaborative works
Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness, iScience (2021)

Daniel Forger

Department of Mathematics, U of Michigan, USA

Collaborative works
Inferring causality in biological oscillators, Bioinformatics (2021)
A Period2 Phosphoswitch Regulates and Compensates Circadian Period, Molecular Cell (2015)
Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms, CPT:PSP (2013)
A Mechanism for Robust Circadian Timekeeping via stoichiometric balance, Mol Syst Biol (2012)
On the Existence and Uniqueness of Biological Clock Models Matching Experimental Data, SIAM J APPL MATH (2012)

Jonathan Tyler

Department of Mathematics, U of Michigan, USA

Collaborative works
Inferring causality in biological oscillators, Bioinformatics (2021)

Jinsu Kim

Department of Mathematics, POSTECH, Republic of Korea

Collaborative works
Computational translation framework identifies biochemical reaction networks with special topologies and their long-term dynamics, SIAM J APPL MATH (2023)
Derivation of stationary distributions of biochemical reaction networks via structure transformation Communications Biology (2021)

Eder Zavala

Institute of Metabolism and Systems Research MRC Skills Development Fellow, University of Birmingham

Collaborative works
Wearable technology and systems modeling for personalized chronotherapy, Curr. Opin. Syst. Biol. (2020)

Yangjin Kim

Department of Mathematics, Konkuk University, Republic of Korea

Optimal regulation of tumor-associated neutrophils in cancer progression, Royal Society Open Science (2022) 

Eduardo R. Mendoza

Department of Mathematics and Statistics, De La Salle University, Republic of the Philippines

Management and control of schistosomiasis in Agusan del Sur, Philippines: A modeling study (submitted)
Positive equilibria of power-law kinetics on networks with independent linkage classes (submitted)
Weakly reversible CF-decompositions of chemical kinetic systems, accepted for Journal of Mathematical Chemistry 

Oleg A. Igoshin

Department of Bioengineering, Rice University, USA

Beyond microtubules: The cellular environment at the
endoplasmic reticulum attracts proteins to the nucleus, enabling nuclear transport, iScience (2024)

Won Chang

Department of Statistics, Seoul National University

Imputing Missing Sleep Data from Wearables with Neural Networks in Real-World Settings

Minseok Seo

Department of Computer Convergence Software, Korea University, Sejong

scLENS: data-driven signal detection for unbiased scRNA-seq data analysis, Nature Communications (2024)
scICE: Enhancing Clustering Reliability and Efficiency of scRNA-seq Data with Multi-Cluster Label Consistency Evaluation, Nature Communications (2025)

Jong-Eun Park

Graduate School of Medical Science and Engineering, KAIST

scLENS: data-driven signal detection for unbiased scRNA-seq data analysis, Nature Communications (2024)
scICE: Enhancing Clustering Reliability and Efficiency of scRNA-seq Data with Multi-Cluster Label Consistency Evaluation, Nature Communications (2025)

Jong Kyoung Kim

Department of Life Sciences, Pohang University of Science and Technology (POSTECH)

scICE: Enhancing Clustering Reliability and Efficiency of scRNA-seq Data with Multi-Cluster Label Consistency Evaluation, Nature Communications (2025)

Jeongbin Park

School of Biomedical Convergence Engineering, Pusan National University

stLENS identifies unbiased complex spatial patterns in spatial transcriptomics data

William Ott

Department of Mathematics, University of Houston

Noisy delay denoises biochemical oscillators, Phys. Rev. Lett. (2024)

Biology

Choogon Lee

Dept. of Biomedical Sciences & Neuroscience, Florida State U., USA

Collaborative works
Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis, PNAS (2020)
Stability of the circadian system requires a robust degradation of PERIOD, Current Biol (2017)
A tunable artificial circadian clock in clock-defective mice, Nature Commun (2015)

David Virshup

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore

Collaborative works
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch, PNAS (2020)
CK1 protein kinases prime the PER2 circadian phosphoswitch, PNAS (2018)
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period, Molecular Cell (2015)

Carla Finkielstein

Department of Biological Sciences, Virginia Tech, USA

Collaborative works
A systems biology approach identifies hidden regulatory connections between the circadian and cell-cycle checkpoints, Front Physiol (2020)
Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein MDM2, Science Signal (2018)
A systems- driven experimental approach reveals the complex regulatory distribution of p53 by circadian factors, PNAS (2016)

Christian I. Hong

Pharmacology and Systems Physiology, U of Cincinnati, USA

Collaborative works
Modeling reveals a key mechanism for light-dependent phase shifts of Neurospora circadian rhythms, Biophys. J. (2018)

Matthew Bennett

Department of Biosciences, Rice University, USA

Collaborative works
Long-range temporal coordination of gene expression in spatially extended synthetic microbial consortia, Nature Chem Biol (2019)
The relationship between deterministic and stochastic quasi-steady-state approximation, BMC Syst Biol (2015)
Emergent genetic oscillations in a synthetic microbial consortium, Science (2015)
The validity of quasi-steady-state approximations in discrete stochastic simulations, Biophys. J. (2014)
Molecular mechanisms that regulate the coupled period of the mammalian circadian clock, Biophys. J. (2014)

Dae-Jin Yun

Department of Biomedical Science & Engineering, Konkuk University, Republic of Korea

Collaborative works
Rheostatic control of ABA signaling through HOS15-mediated OST1 degradation, Molecular Plant (2019)

Woe Yeon Kim

Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Republic of Korea

Collaborative works
Rheostatic control of ABA signaling through HOS15-mediated OST1 degradation, Molecular Plant (2019)

Eun Young Kim

Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Republic of Korea

Collaborative works
Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons, PNAS (2022) 

Sara Aton

Department of Molecular, Cellular, and Developmental Biology, U of Michigan

Collaborative works
Possible “non-clock” functions of circadian clock genes – Potential roles in sleep, stress, and memory, Biochemical Pharmacology (2021)

Matias D. Zurbriggen

Institute of Synthetic Biology and CEPLAS, Heinrich Heine University Düsseldorf, Germany

Collaborative works
Possible “non-clock” functions of circadian clock genes – Potential roles in sleep, stress, and memory, Biochemical Pharmacology (2021)

Robbert Havekes

Department of Biology, University of Pennsylvania, USA
Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, The Netherlands

Collaborative works
Possible “non-clock” functions of circadian clock genes – Potential roles in sleep, stress, and memory, Biochemical Pharmacology (2021)

Yoshitaka Fukada

Department of Biophysics and Biochemistry (UG), Department of Biological Sciences (GR), Graduate School of Science, University of Tokyo, Japan

Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals (submitted)
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch, PNAS (2020)

Sooyeon Suh

Department of Psychology, Sungshin Women’s University, Republic of Korea

Validation of a Korean version of the Metacognitions Questionnaire-Insomnia (MCQ-I) and development of shortened versions of the rating scale: a random forest approach, Sleep Med. (2022)

Mathias Foo

School of Engineering, University of Warwick, Coventry University, United Kingdom

 Modeling of Plant Circadian Clock for CharacterizingHypocotyl Growth under Different Light QualityConditions, in silico Plants (2022)

Medicine

Eun Yeon Joo

Department of Neurology, Neuroscience Center, Samsung Medical Center, Republic of Korea

Collaborative works
Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness, iScience (2021)
A real-time, personalized sleep intervention using mathematical modelling and wearable devices, Sleep (2023)

Su Jung Choi

Graduate School of Clinical Nursing Science, Sungkyunkwan University, Republic of Korea

Collaborative works
Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness, iScience (2021)
A real-time, personalized sleep intervention using mathematical modelling and wearable devices, Sleep (2023)

Jeong Whun Kim

Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Republic of Korea

Collaborative works
Combined unsupervised-supervised machine learning for phenotyping complex diseases with its application to obstructive sleep apnea, Scientific Reports (2021)

Young Il Koh

Department of Internal Medicine, Seoul National University Hospital, Republic of Korea

Collaborative works
Chemotherapy delivery time affects anti-lymphoma treatment outcome in a sex-dependent manner (submitted)

Jee Hyun Kim

Department of Neurology, Ewha Womans University Medical Center, Republic of Korea

Collaborative works
Imputing Missing Sleep Data from Wearables with Neural Networks in Real-World Settings, Sleep (2023)

Seockhoon Chung

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea

Collaborative works
Validation of a Korean version of the Metacognitions Questionnaire-Insomnia (MCQ-I) and development of shortened versions of the rating scale: a random forest approach, Sleep Med. (2022)
Data-driven Shortened Insomnia Severity Index: A Machine Learning Approach, Sleep Breath (2024)
Cancer-related Dysfunctional Beliefs and Attitude about Sleep-6 (C-DBAS-6): a practical and accurate shortened version using XGBoost and SymScore, Sleep and Biological Rhythms (2025)
Machine learning approached a 14-item shortened version of the Positive and Negative Sleep Appraisal Measure (PANSAM-14)

Heon-Jeong Lee

Department of Psychiatry, Korea University College of Medicine, Republic of Korea
Chronobiology Institute, Korea University, Republic of Korea

Collaborative works
Highly Accurate Prediction of Mood Episodes in Mood Disorder Patients Using Sleep and Circadian Rhythm Features from Wearables (Under Review in Nature Mental Health)
Causal Dynamics of Sleep, Circadian Rhythm, and Mood in Major Depression and Bipolar Disorder Patients: Insights from Longitudinal Wearable Device Data, (Under Review in eBioMedicine)

Suein Choi

College of Medicine, The Catholic University of Korea

Collaborative works
Beyond Michaelis- Menten: A Modified Enzyme Kinetics Equation Improves Drug Metabolism Prediction in Bottom-Up PBPK Modeling

Jeong-Hyun Kim

Seoul National University Hospital

Collaborative works
Identifying risk factors of PTSD among a nationwide cohort of firefighters using a machine learning algorithm

Inês M.A. Ribeiro

Institute of Medical Psychology, LMU Munich

Collaborative works
Friend or foe: how insects see their peers

Bei Bei

Turner Institute for Brain and Mental Health, Monash University, Australia

Collaborative works
Application of mathematical model of sleep to Australian teenager cohort

Ki-Young Jeong

Department of Neurology, Seoul National University Hospital

Collaborative works
Delayed Circadian Rhythm in Restless Legs Syndrome and its Association with Symptom Severity: An Actigraphy-Based Study

Pharmacology

Cheng Chang

Clinical Pharmacology, Pfizer Global Product Development, Pfizer Inc, USA

Collaborative works
Systems approach reveals photosensitivity and PER2 level as determinants of clock modulator efficacy, Mol Syst Biol (2019)
Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms, CPT:PSP (2013)

Francois Gaudreault

Clinical Pharmacology and Pharmacometrics, Biogen Inc, USA

Collaborative works
Systems approach reveals photosensitivity and PER2 level as determinants of clock modulator efficacy, Mol Syst Biol (2019)

Hwi‐yeol Yun

College of Pharmacy, Chungnam National University, Republic of Korea

Collaborative works
Beyond the Michaelis-Menten: Prediction of in vivo clearance for drugs with low KM, Clin Transl Sci (2020)
Beyond the Michaelis-Menten: Accurate Prediction of Drug Interactions  through Cytochrome P450 Induction, CPT (2023)
Optimizing enzyme inhibition analysis: precise estimation with a single inhibitor concentration, Nature Communications (2025)

Sang Kyum Kim

College of Pharmacy, Chungnam National University, Republic of Korea

Collaborative works
Beyond the Michaelis-Menten: Prediction of in vivo clearance for drugs with low KM, Clin Transl Sci (2020)
Beyond the Michaelis-Menten: Accurate Prediction of Drug Interactions  through Cytochrome P450 Induction, CPT (2023)
Optimizing enzyme inhibition analysis: precise estimation with a single inhibitor concentration, Nature Communications (2025)

Jungwoo Chae

College of Pharmacy, Chungnam National University, Republic of Korea

Collaborative works
Beyond the Michaelis-Menten: Accurate Prediction of Drug Interactions  through Cytochrome P450 Induction, CPT (2023)

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